First report of blaIMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli sequence type 131
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Date
Authors
Stoesser, Nicole
Sheppard, Anna E.
Peirano, Gisele
Sebra, Robert
Lynch, Tarah
Anson, Luke
Kasarskis, Andrew
Motyl, Mary R.
Crook, Derrick W.
Pitout, Johann D.D.
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract
The blaIMP-14 carbapenem resistance gene has largely previously been observed in
Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and
sequencing of carbapenem-resistant E. coli, we identified an ST131 strain harboring
blaIMP-14 within a class 1 integron, itself nested within a ~54kb multi-drug resistance
region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in
the ST131 lineage is of potential clinical concern.
Description
Keywords
Pseudomonas aeruginosa, Acinetobacter spp., Global surveillance
Sustainable Development Goals
Citation
Stoesser, N, Sheppard, AE, Peirano, G, Sebra, R, Lynch, T, Anson, L, Kasarskis, A, Motyl, MR, Crook, DW & Pitout, JDD 2016, 'First report of blaIMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli sequence type 131', Antimicrobial Agents and Chemotherapy, vol. 60, no. 8, pp. 5068-5071.