Lung function decline is accelerated in South Africans with cystic fibrosis

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dc.contributor.author Masekela, Refiloe
dc.contributor.author Olorunju, S.
dc.contributor.author Green, Robin J.
dc.contributor.author Magidimisa, N.T.
dc.date.accessioned 2016-04-25T09:50:59Z
dc.date.available 2016-04-25T09:50:59Z
dc.date.issued 2016
dc.description.abstract BACKGROUND : Poor nutritional status has been shown to be associated with a significant decline in lung function in patients with cystic fibrosis. There are few data published on the lung function decline and the effects of nutritional status in cystic fibrosis (CF) in South Africa. AIM : To assess anthropometric parameters (weight, height, body mass index Z-score) in relation to lung function parameters in CF patients. METHODOLOGY : A retrospective chart review of clinical records of participants over the age of five years attending the CF clinic at Steve Biko Academic Hospital from 2005 to 2010. RESULTS : Twenty files were reviewed for lung function, anthropometric measurements, gender and CF-causing mutations. For anthropometric measurements the average changes were –0.8, –0.5 and 2.0 for weight, BMI and height Z-scores, respectively. A decline in FEV1 of –25.3 (95% CI 39.4; –13.3) over the five-year period was noted, with an average decline of 5.3% per year. For FEF25-75, the average change was –22.4 (95% CI-34.6; –10.2) with a decline of 4.5% per year. Using multivariate analysis, the FEV1 was found to be significantly influenced by: age –3.96 (95% CI –7.4; –0.5); p = 0.03, weight 1.8 (95% CI –3.4; –0.9); p = 0.04, BMI Z-score 4.3 (95% CI 5.3; 23.3); p = 0.02 and gender (p = 0.02). The FEF25-75 was significantly influenced by BMI Z-score and gender. CONCLUSION : The average lung function decline per year for FEV1 was higher than that seen in developed countries. The decline in FEV1 was related to gender, age, weight and BMI. The decline in FEF25-75 was affected only by BMI Z-score and gender. en_ZA
dc.description.department Paediatrics and Child Health en_ZA
dc.description.librarian am2016 en_ZA
dc.description.uri http://www.safpj.co.za/index.php/safpj en_ZA
dc.description.uri http://medpharm.tandfonline.com/loi/ojfp20#.VgJFAVQaJHg en_ZA
dc.identifier.citation Masekela, R, Olorunju, S, Greena, RJ & Magidimisa, NT 2016, 'Lung function decline is accelerated in South Africans with cystic fibrosis', South African Family Practice, vol. 58, no. 1, pp. 24-27. en_ZA
dc.identifier.issn 2078-6190 (print)
dc.identifier.issn 2078-6204 (online)
dc.identifier.other 10.1080/20786190.2015.1078156
dc.identifier.uri http://hdl.handle.net/2263/52142
dc.language.iso en en_ZA
dc.publisher MedPharm Publications en_ZA
dc.rights © 2016 The Author(s). Open Access article distributed under the terms of the Creative Commons License [CC BY-NC-ND 4.0]. en_ZA
dc.subject Body mass index en_ZA
dc.subject Growth en_ZA
dc.subject Nutrition en_ZA
dc.subject Pancreatic insufficiency en_ZA
dc.subject Spirometry en_ZA
dc.subject Cystic fibrosis (CF) en_ZA
dc.title Lung function decline is accelerated in South Africans with cystic fibrosis en_ZA
dc.type Article en_ZA


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