Browsing Arthur (Articles) by UP Author "Pepper, Michael Sean"

Browsing Arthur (Articles) by UP Author "Pepper, Michael Sean"

Sort by: Order: Results:

  • The c-Myc/TBX3 axis promotes cellular transformation of sarcoma-initiating cells 
    Damerell, Victoria; Ambele, Melvin Anyasi; Salisbury, Shanel; Neumann-Mufweba, Alexis; Durandt, Chrisna; Pepper, Michael Sean; Prince, Sharon (Frontiers Media S.A., 2022-01-25)
    Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical management is highly complex. This is partly due to a lack of understanding of the molecular mechanisms underpinning the transformation of ...
  • Characterization of signalling pathways that link apoptosis and autophagy to cell death induced by estrone analogues which reversibly depolymerize microtubules 
    Mercier, Anne Elisabeth; Prudent, Renaud; Pepper, Michael Sean; De Koning, Leanne; Nolte, Elsie; Peronne, Lauralie; Nel, Marcel; Lafanechere, Laurence; Joubert, Annie M. (MDPI, 2021-01-29)
    The search for novel anti-cancer compounds which can circumvent chemotherapeutic drug resistance and limit systemic toxicity remains a priority. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)15- tetraene-3-ol-17one (ESE-15-one) ...
  • Coronavirus host genetics South Africa (COHG-SA) database—a variant database for gene regions associated with SARS-CoV-2 outcomes 
    Barmania, Fatima; Mellet, Juanita; Ryder, Megan A.; Ford, Graeme R.; Herd, Candice L.; Tamuhla, Tsaone; Hendricks, Candice; Giles, Rachel; Kalua, Thumbiko; Joubert, Fourie; Tiffin, Nicki; Pepper, Michael Sean (Springer nature, 2022-08)
    The SARS-CoV-2 virus is responsible for the COVID-19 global public health emergency, and the disease it causes is highly variable in its clinical presentation. Clinical phenotypes are heterogeneous both in terms of ...
  • A COVID-19 vaccine : big strides come with big challenges 
    Mellet, Juanita; Pepper, Michael Sean (MDPI, 2021-01)
    As of 8 January 2021, there were 86,749,940 confirmed coronavirus disease 2019 (COVID19) cases and 1,890,342 COVID-19-related deaths worldwide, as reported by the World Health Organization (WHO). In order to address the ...
  • Enabling the use of health data for research : developing a POPIA code of conduct for research in South Africa 
    Staunton, Ciara; Adams, R.; Botes, M.; De Vries, J.; Labuschaigne, M.; Loots, G.; Mahomed, S.; Loideain, N.N.; Olckers, A.; Pepper, Michael Sean; Pope, A.; Ramsay, M. (Health and Medical Publishing Group, 2021-04-01)
    Globally, there has been a move toward 'open science' that includes the sharing of health data for research. The importance of data sharing for research is generally acknowledged, but this must only be done with legal and ...
  • High resolution HLA ∼A, ∼B, ∼C, ∼DRB1, ∼DQA1, and ∼DQB1 diversity in South African populations 
    Tshabalala, Mqondisi; Mellet, Juanita; Vather, Kuben; Nelson, Derrick; Mohamed, Fathima; Christoffels, Alan; Pepper, Michael Sean (Frontiers Media S.A., 2022-03-04)
    BACKGROUND : Lack of HLA data in southern African populations hampers disease association studies and our understanding of genetic diversity in these populations. We aimed to determine HLA diversity in South African ...
  • An in vitro and in vivo comparison of osteogenic differentiation of human mesenchymal stromal/stem cells 
    Mollentze, Jamie; Durandt, Chrisna; Pepper, Michael Sean (Hindawi Limited, 2021-09)
    The use of stem cells in regenerative medicine, including tissue engineering and transplantation, has generated a great deal of enthusiasm. Mesenchymal stromal/stem cells (MSCs) can be isolated from various tissues, most ...
  • Inclusivity and diversity : integrating international perspectives on stem cell challenges and potential 
    Fears, Robin; Akutsu, Hidenori; Alentajan-Aleta, Lara Theresa; Caicedo, Andres; De Carvalho, Antonio Carlos Campos; Colic, Miodrag; Cornish, Jillian; Cossu, Giulio; Debre, Patrice; Dierckxsens, Geoffrey; El-Badri, Nagwa; Griffin, George; Hsieh, Patrick Chingo-Ho; Inamdar, Maneesha S.; Kumar, Pradeep; Abraham, Consuelo Macias; Maciulaitis, Romaldas; Mahtab, Mamun Al; O’Brien, Fergal J.; Pepper, Michael Sean; Ter Meulen, Volker (Cell Press, 2021-08-10)
    Regenerative medicine has great potential. The pace of scientific advance is exciting and the medical opportunities for regeneration and repair may be transformative. However, concerns continue to grow, relating to problems ...
  • Molecular mechanisms underpinning sarcomas and implications for current and future therapy 
    Damerell, Victoria; Pepper, Michael Sean; Prince, Sharon (Springer, 2021-06)
    Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical management is highly challenging due to their heterogeneity and insensitivity to current treatments. Although there have been advances in ...
  • Questions about the HELIX trial 
    Kali, Gugu T.J.; Pillay, Shakti; Pepper, Michael Sean; Horn, Alan R. (Elsevier, 2021-12)
    In the HELIX study, Sudhin Thayyil and colleagues suggested that all low-income and middle-income countries (LMICs) should immediately suspend use of cooling in neonates. The reported absence of benefit and increased ...
  • Single-cell transcriptome analysis of human adipose-derived stromal cells identifies a contractile cell subpopulation 
    Wolmarans, Elize; Mellet, Juanita; Durandt, Chrisna; Joubert, Fourie; Pepper, Michael Sean (Hindawi Limited, 2021-04)
    The potential for human adipose-derived stromal cells (hASCs) to be used as a therapeutic product is being assessed in multiple clinical trials. However, much is still to be learned about these cells before they can be ...
  • Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy should not be discontinued in low- and middle-income countries 
    Ballot, Daynia E.; Ramdin, Tanusha D.; Bandini, Rossella M.; Nakwa, Firdose; Velaphi, Sithembiso; Coetzee, Melantha; Masemola, Khomotso; Kali, Gugulabatembunamahlubi J.D.; Horn, Alan R.; Pillay, Shakti; Van Rensburg, Jeanne; Pepper, Michael Sean (Health and Medical Publishing Group, 2021-12)
    Perinatal asphyxia is a major cause of death and disability in children. Therapeutic hypothermia (TH) has become a standard of care for newborn infants who have sustained hypoxic ischaemic encephalopathy (HIE) due to ...
  • Viruses, variants and vaccines 
    Cowan, Don A.; Burton, Stephanie G.; Rybicki, E.P.; Williamson, A.-L.; Dorrington, R.A.; Pepper, Michael Sean (Health and Medical Publishing Group, 2021-05)
    The current SARS-CoV-2 pandemic has brought a number of major global clinical, sociological and economic issues into sharp focus. We address some of these issues, focusing on short-term factors such as virus mutations and ...
  • When cells become medicines : a South African perspective 
    Viljoen, Ignatius M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2021-11)
    The discovery of human leucocyte antigen (HLA), serological matching and HLA-typing techniques, combined with the development of immunosuppressive medicines and improvements in infection control, have opened the way to ...