A Malaysia 97 monovalent foot-and-mouth disease vaccine (> 6PD(50)/dose) protects pigs against challenge with a variant FMDV A SEA-97 lineage virus, 4 and 7 days post vaccination

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dc.contributor.author Singanallur, Balasubramanian Nagendrakumar
dc.contributor.author Nguyen, Thi Thu Hong
dc.contributor.author Fosgate, Geoffrey T.
dc.contributor.author Morris, Michelle Jacqueline
dc.contributor.author Davis, Andrew
dc.contributor.author Giles, Michelle
dc.contributor.author Kim, Van Phuc
dc.contributor.author Quach, Vo Ngon
dc.contributor.author Le, Thi Thu Phuong
dc.contributor.author Nguyen, Ngoc Hong Phuc
dc.contributor.author Tran, Xuan Hanh
dc.contributor.author Vo, Van Hung
dc.contributor.author Le, Thi Quynhanh
dc.contributor.author Tran, Minh Tan
dc.contributor.author Ngo, Thanh Long
dc.contributor.author Vosloo, Wilna
dc.date.accessioned 2016-02-29T08:32:21Z
dc.date.available 2016-02-29T08:32:21Z
dc.date.issued 2015-08
dc.description.abstract Pigs play a significant role during outbreaks of foot-and-mouth disease (FMD) due to their ability to amplify the virus. It is therefore essential to determine what role vaccination could play to prevent clinical disease and lower virus excretion into the environment. In this study we investigated the efficacy of the double oil emulsion A Malaysia 97 vaccine (>6PD50/dose) against heterologous challenge with an isolate belonging to the A SEA-97 lineage at 4 and 7 days post vaccination (dpv). In addition, we determined whether physical separation of pigs in the same room could prevent virus transmission. Statistically there was no difference in the level of protection offered by 4 and 7 dpv. However, no clinical disease or viral RNA was detected in the blood of pigs challenged 4 dpv, although three of the pigs had antibodies to the non-structural proteins (NSPs), indicating viral replication. Viral RNA was also detected in nasal and saliva swabs, but on very few occasions. Two of the pigs vaccinated seven days prior to challenge had vesicles distal from the injection site, but on the inoculated foot, and two pigs had viral RNA detected in the blood. One pig sero-converted to the NSPs. In contrast, all unvaccinated and inoculated pigs had evidenceof infection. No infection occurred in any of the susceptible pigs in the same room, but separated from the infected pigs, indicating that strict biosecurity measures were sufficient under these experimental conditions to prevent virus transmission. However, viral RNA was detected in the nasal swabs of one group of pigs, but apparently not at sufficient levels to cause clinical disease. Vaccination led to a significant decrease in viral RNA in vaccinated pigs compared to unvaccinated and infected pigs, even with this heterologous challenge, and could therefore be considered as a control option during outbreaks. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship Cattle Council of Australia, Australian Dairy Farmers, Australian Lot Feeders Association, Wool Producers Australia,Sheepmeat Council of Australia, Australian Pork Limited and the Goat Industry Council of Australia through the Meat and Livestock Australia Donor Company matching arrangements with the Australian Government (Project PSH 0558). en_ZA
dc.description.uri http://www.elsevier.com/locate/vaccine en_ZA
dc.identifier.citation Singanallur, BN, Nguyen, TTH, Fosgate, TG, Morris, MJ, Davis, A, Giles, M, Kim,VP, Quach, VN, Le, TTP, Nguyen, NHP, Tran, XH, Vo, VH, Le, TQ, Tran, MT, Ngo, TL & Vosloo, W 2015, 'A Malaysia 97 monovalent foot-and-mouth disease vaccine (> 6PD(50)/dose) protects pigs against challenge with a variant FMDV A SEA-97 lineage virus, 4 and 7 days post vaccination', Vaccine, vol. 33, pp. 4513-4519. en_ZA
dc.identifier.issn 0264-410X (print)
dc.identifier.issn 1873-2518 (online)
dc.identifier.other 10.1016/j.vaccine.2015.07.014
dc.identifier.uri http://hdl.handle.net/2263/51583
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.relation.requires Adobe Acrobat Reader en
dc.rights © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/). en_ZA
dc.subject Serotype A en_ZA
dc.subject Pigs en_ZA
dc.subject Vaccination en_ZA
dc.subject Early protection en_ZA
dc.subject Heterologous challenge en_ZA
dc.subject Foot-and-mouth disease en_ZA
dc.subject FMD en_ZA
dc.title A Malaysia 97 monovalent foot-and-mouth disease vaccine (> 6PD(50)/dose) protects pigs against challenge with a variant FMDV A SEA-97 lineage virus, 4 and 7 days post vaccination en_ZA
dc.type Article en_ZA


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