Premature collagen fibril formation, fibroblast-mast cell interactions and mast cell-mediated phagocytosis of collagen in keloids

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dc.contributor.author Arbi, Sandra
dc.contributor.author Eksteen, Ehren Cronje
dc.contributor.author Oberholzer, Hester Magdalena
dc.contributor.author Taute, Helena
dc.contributor.author Bester, Megan Jean
dc.date.accessioned 2016-02-10T08:44:08Z
dc.date.issued 2015-04
dc.description.abstract Keloids are benign hyper-proliferative growths of fibrous tissue, where increased fibroblast activity results in abnormal collagen deposition. Excessive inflammation is a characteristic feature of keloids but little is known about the underlying ultrastructural features of keloids related to collagen processing, fibril and fibre formation, the interaction between fibroblasts and associated collagen fibres and mast cells. In this study, the ultrastructure of the dermis of keloid patients was evaluated using light and transmission electron microscopy techniques. Abnormal intracellular premature collagen fibril formation was observed. Phagocytosis of collagen fibrils by mast cells was a common ultrastructural feature of keloid tissue as was a close or direct association between fibroblasts and mast cells. Based on these findings and recent advances in knowledge related to collagen synthesis, fibril formation and processing we hypothesise that keloid formation is primary due to abnormal collagen synthesis where the consequent accumulation of collagen fibres causes increased mast cell recruitment and collagen phagocytosis. Subsequent release of mast cell derived mediators then promotes further collagen synthesis. The observation of early formation in keloid tissue of premature insoluble collagen fibrils supports previous studies that enzymes such as procollagen C-proteinase are important early therapeutic targets. en_ZA
dc.description.embargo 2016-04-30
dc.description.librarian hb2015 en_ZA
dc.description.uri http://www.tandfonline.com/ en_ZA
dc.identifier.citation Arbi, S, Eksteen, EC, Oberholzer, HM, Taute, H & Bester, MJ 2015, 'Premature collagen fibril formation, fibroblast-mast cell interactions and mast cell-mediated phagocytosis of collagen in keloids', Ultrastructural Pathology, vol. 39, no. 2, pp. 95-103. en_ZA
dc.identifier.issn 0191-3123 (print)
dc.identifier.issn 1521-0758 (online)
dc.identifier.other 10.3109/01913123.2014.981326
dc.identifier.uri http://hdl.handle.net/2263/51312
dc.language.iso en en_ZA
dc.publisher Taylor and Francis en_ZA
dc.rights © 2015 Taylor and Francis. This is an electronic version of an article published in Ultrastructural Pathology, vol.39, no. 2, pp. 95-103, 2015.doi : 10.3109/01913123.2014.981326. Ultrastructural Pathology is available online at : http://www.tandfonline.com/. en_ZA
dc.subject Collagen en_ZA
dc.subject Intracellular en_ZA
dc.subject Fibre en_ZA
dc.subject Fibroblast en_ZA
dc.subject Keloid en_ZA
dc.subject Mast cell en_ZA
dc.title Premature collagen fibril formation, fibroblast-mast cell interactions and mast cell-mediated phagocytosis of collagen in keloids en_ZA
dc.type Postprint Article en_ZA


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