Six bufadienolides were isolated from Tylecodon grandiflorus (Burm. f.) Toelken. The paretic syndrome, krimpsiekte, could be induced in sheep either by repeated oral administration of small quantities of plant material or the intravenous injection of small quantities of certain bufadienolides. A mild to moderate, acute to subacute, multifocal cardiomyopathy was evident in sheep poisoned by both the plant and the bufadienolides.
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