Comparative aspects of immunity and vaccination in human and bovine trichomoniasis : a review

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dc.contributor.author Chapwanya, Aspinas
dc.contributor.author Usman, Abubakar Yusha’u
dc.contributor.author Irons, Pete Charles
dc.date.accessioned 2015-11-13T06:08:21Z
dc.date.issued 2016-01
dc.description.abstract Trichomonas vaginalis and Tritrichomonas foetus are important extracellular protozoans that cause, respectively, human and bovine venereal diseases. Trichomonads are extracellular parasites that primarily inhabit the genital tracts of the mammalian hosts where they overcome the mucus barrier and parasitize mucosa by contact-dependent or contact-independent cytotoxicity. Transient immunity is usually achieved by the host after clinical infection. At present, vaccination in cattle reduces infection rates and reproductive wastage in affected herds. After vaccination, immunoglobulin G (IgG) levels increase in systemic circulation while immunoglobulin A (IgA) levels rise in the vagina. Only moderate protection is conferred by means of vaccination. Future vaccine development strategies are needed for cattle to enhance the antigenic component or use adjuvant that strongly activates the innate immune response to produce safe and potent vaccines. This paper reviews the current knowledge of the immunology of trichomoniasis infection and the challenges and potential of vaccines in the control of the infection in human and bovine trichomoniasis. en_ZA
dc.description.embargo 2017-01-30
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship Institute of Food, Nutrition and Well-being (IFNuW) from the University of Pretoria, South Africa. en_ZA
dc.description.uri http://link.springer.com/journal/11250 en_ZA
dc.identifier.citation Chapwanya, A, Usman, AY & Irons, PC 2016, 'Comparative aspects of immunity and vaccination in human and bovine trichomoniasis', Tropical Animal Health and Production, vol. 48, no. 1, pp-1-7. en_ZA
dc.identifier.issn 0049-4747 (print)
dc.identifier.issn 1573-7438 (online)
dc.identifier.other 10.1007/s11250-015-0909-1
dc.identifier.other 6603165622
dc.identifier.other O-6401-2014
dc.identifier.uri http://hdl.handle.net/2263/50444
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.relation.requires Adobe Acrobat Reader en
dc.rights © Springer Science+Business Media Dordrecht 2015. The original publication is available at : http://link.springer.comjournal/11250. en_ZA
dc.subject Tritrichomonas foetus en_ZA
dc.subject Trichomonas vaginalis en_ZA
dc.subject Venereal infection en_ZA
dc.subject Immunity en_ZA
dc.subject Vaccination en_ZA
dc.subject Bovine en_ZA
dc.subject Fertility en_ZA
dc.title Comparative aspects of immunity and vaccination in human and bovine trichomoniasis : a review en_ZA
dc.type Postprint Article en_ZA


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