A descriptive study to provide evidence of the teratogenic and cellular effects of sibutramine and ephedrine on cardiac- and liver-tissue of chick embryos

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dc.contributor.author Oberholzer, Hester Magdalena
dc.contributor.author Van der Schoor, Ciska
dc.contributor.author Taute, Helena
dc.contributor.author Bester, Megan Jean
dc.date.accessioned 2015-09-28T10:07:41Z
dc.date.issued 2015-08
dc.description.abstract Exposure to drugs during pregnancy is a major concern, as some teratogenic compounds can influence normal foetal development. Although the use of drugs during pregnancy should generally be avoided, exposure of the developing foetus to teratogens may occur unknowingly since these compounds may be hidden in products that are being marketed as “all natural”. The aim of the current study was to investigate the possible teratogenic and cellular effects of sibutramine - a serotonin-norepinephrine reuptake inhibitor used in the treatment of obesity - on the heart and liver tissue of chick embryos. Ephedrine was used as a positive control. The chick embryo model was chosen because it has been used in studying developmental and experimental biology and teratology with great success. The embryos were exposed to three different concentrations of sibutramine and ephedrine respectively. The results obtained revealed that both compounds exhibited embryotoxicity when compared to the control groups. Liver and heart tissue of the exposed embryos was severely affected by these compounds in a dose-related manner. Morphology similar to that of muscle dystrophy was observed in the heart, where the muscle tissue was infiltrated by adipose and connective tissue. Severe liver steatosis was also noted. A more in-depth investigation into the molecular pathways involved might provide more information on the exact mechanism of toxicity of these products influencing embryonic development. en_ZA
dc.description.embargo 2016-08-31
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship National research foundation (NRF) en_ZA
dc.description.uri http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0029 en_ZA
dc.identifier.citation Oberholzer, HM, Van der Schoor, C, Taute, H & Bester, MJ 2015, 'A descriptive study to provide evidence of the teratogenic and cellular effects of sibutramine and ephedrine on cardiac- and liver-tissue of chick embryos', Microscopy Research and Technique, vol. 78, no. 8, pp. 737-746. en_ZA
dc.identifier.issn 1059-910X (print)
dc.identifier.issn 1097-0029 (online)
dc.identifier.other 10.1002/jemt.22539
dc.identifier.uri http://hdl.handle.net/2263/50069
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2015 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article : A descriptive study to provide evidence of the teratogenic and cellular effects of sibutramine and ephedrine on cardiac- and liver-tissue of chick embryos, Microscopy Research and Technique, vol. 78, no. 8, pp. 737-746, 2015. doi : 10.1002/jemt.22539. The definite version is available at : http://onlinelibrary.wiley.comjournal/10.1002/(ISSN)1097-0029. en_ZA
dc.subject Sibutramine en_ZA
dc.subject Ephedrine en_ZA
dc.subject Teratogenic effects en_ZA
dc.subject Heart tissue en_ZA
dc.subject Liver tissue en_ZA
dc.title A descriptive study to provide evidence of the teratogenic and cellular effects of sibutramine and ephedrine on cardiac- and liver-tissue of chick embryos en_ZA
dc.type Postprint Article en_ZA


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