Browsing Radiology by Author "Mercier, Anne Elisabeth"

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Exposure of breast and lung cancer cells to a novel estrone analog prior to radiation enhances Bcl-2-mediated cell death

Nolte, Elsie Magdalena; Joubert, Annie M.; Lakier, Roy; Van Rensburg, Ado; Mercier, Anne Elisabeth (MDPI Publishing, 2018)

Following exposure of cells to gamma-radiation, a cascade of intracellular consequences may be observed in a semitemporal manner. This includes deoxyribonucleic acid (DNA) damage and reactive oxygen species (ROS) ...
Intracellular signaling responses induced by radiation within an in vitro bone metastasis model after pre-treatment with an estrone analogue

Helena, Jolene Michelle; Joubert, Anna Margaretha; Mabeta, Peaceful Lucy; Coetzee, Magdalena; Lakier, Roy; Mercier, Anne Elisabeth (MDPI, 2021-08-17)

2-Ethyl-3-O-sulfamoyl-estra-1,3,5(10)16-tetraene (ESE-16) is an in silico-designed estradiol analogue which has improved the parent compound’s efficacy in anti-cancer studies. In this proofof- concept study, the potential ...

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