Cytotoxicity of diplodiatoxin, dipmatol and diplonine, metabolites synthesized by Stenocarpella maydis
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Date
Authors
Masango, Mxolisi Goodwill
Ferreira, Gezina Catharina Helena
Ellis, Charlotte Elizabeth
Elgorashi, Esam E.
Botha, C.J. (Christoffel Jacobus)
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
The cytotoxicity of three Stenocarpella maydis metabolites (diplodiatoxin, dipmatol and
diplonine) was investigated on Neuro-2a, CHO-K1 and MDBK cell lines. Diplodiatoxin was
the most cytotoxic followed by dipmatol. Conversely, diplonine was not cytotoxic. Diplodiatoxin
and dipmatol affected mitochondrial succinate dehydrogenase (MTT assay) and
the overall viability of cells as assessed in real-time (xCELLigence assay). The results obtained
so far indicate that diplodiatoxin and dipmatol exert their toxicity possibly via the
necrotic cell death pathway.
Description
Keywords
Stenocarpella maydis, Diplodiatoxin, Diplonine, Dipmatol, Cytotoxicity, xCELLigence
Sustainable Development Goals
Citation
Masango, MG, Ferreira, GCH, Ellis, CE, Elgorashi, EE & Botha, CJ 2014, 'Cytotoxicity of diplodiatoxin, dipmatol and diplonine, metabolites synthesized by Stenocarpella maydis', Toxicon, vol. 82, pp. 26-29.