Cytotoxicity of diplodiatoxin, dipmatol and diplonine, metabolites synthesized by Stenocarpella maydis
| dc.contributor.author | Masango, Mxolisi Goodwill | |
| dc.contributor.author | Ferreira, Gezina Catharina Helena | |
| dc.contributor.author | Ellis, Charlotte Elizabeth | |
| dc.contributor.author | Elgorashi, Esam E. | |
| dc.contributor.author | Botha, C.J. (Christoffel Jacobus) | |
| dc.date.accessioned | 2015-07-02T05:21:04Z | |
| dc.date.available | 2015-07-02T05:21:04Z | |
| dc.date.issued | 2014-05 | |
| dc.description.abstract | The cytotoxicity of three Stenocarpella maydis metabolites (diplodiatoxin, dipmatol and diplonine) was investigated on Neuro-2a, CHO-K1 and MDBK cell lines. Diplodiatoxin was the most cytotoxic followed by dipmatol. Conversely, diplonine was not cytotoxic. Diplodiatoxin and dipmatol affected mitochondrial succinate dehydrogenase (MTT assay) and the overall viability of cells as assessed in real-time (xCELLigence assay). The results obtained so far indicate that diplodiatoxin and dipmatol exert their toxicity possibly via the necrotic cell death pathway. | en_ZA |
| dc.description.librarian | hb2015 | en_ZA |
| dc.description.sponsorship | National Research Foundation (NRF), International Foundation for Science (IFS) and the Joy Liebenberg Trust Fund. | en_ZA |
| dc.description.uri | http://www.elsevier.com/locate/toxicon | en_ZA |
| dc.identifier.citation | Masango, MG, Ferreira, GCH, Ellis, CE, Elgorashi, EE & Botha, CJ 2014, 'Cytotoxicity of diplodiatoxin, dipmatol and diplonine, metabolites synthesized by Stenocarpella maydis', Toxicon, vol. 82, pp. 26-29. | en_ZA |
| dc.identifier.issn | 0041-0101 (print) | |
| dc.identifier.issn | 1879-3150 (online) | |
| dc.identifier.other | 10.1016/j.toxicon.2014.02.002 | |
| dc.identifier.uri | http://hdl.handle.net/2263/45854 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | Elsevier | en_ZA |
| dc.rights | © 2014 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Toxicon. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Toxicon, vol. 82, pp. 26-29, 2014. doi : 10.1016/j.toxicon.2014.02.002 | en_ZA |
| dc.subject | Stenocarpella maydis | en_ZA |
| dc.subject | Diplodiatoxin | en_ZA |
| dc.subject | Diplonine | en_ZA |
| dc.subject | Dipmatol | en_ZA |
| dc.subject | Cytotoxicity | en_ZA |
| dc.subject | xCELLigence | en_ZA |
| dc.title | Cytotoxicity of diplodiatoxin, dipmatol and diplonine, metabolites synthesized by Stenocarpella maydis | en_ZA |
| dc.type | Postprint Article | en_ZA |