Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines
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Date
Authors
Lall, Namrita
Kishore, Navneet
Binneman, Brigitte
Twilley, Danielle
Van de Venter, Maryna
Du Plessis-Stoman, Debbie
Boukes, Gerhardt
Hussein, Ahmed A.
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor and Francis
Abstract
The present study was carried out to determine the cytotoxic effect of seven plant
extracts and the isolated compounds; syringin and 4-methoxycinnamyl alcohol on
cancerous and non-cancerous cells. The ethanol extract of F. vulgare was found to
exhibit the most significant toxicity with an IC50 value of 19.97 μg/mL on HeLa
cells. Bioassay guided fractionation lead to the isolation of two compounds,
syringin (1) and 4-methoxycinnamyl alcohol (2). Both compounds showed
toxicity against MCF-7, HeLa, and DU145 cancer cell line. The results showed
that compound 2 showed high toxicity against all the cancer cell lines with IC50
values of 14.24, 7.82 and 22.10 μg/mL, respectively. 4-Methoxycinnamyl alcohol
also showed no apoptotic effect in cell cycle analysis after 48 hours at a
concentration of 10 μg/mL. However DNA fragmentation study revealed that,
necrosis took place at a concentration of 10 μg/mL after 48 h exposure.
Description
Keywords
Foeniculum vulgare, Cytotoxicity, 4-Methoxycinnamyl alcohol, Cell cycle analysis, DNA fragmentation
Sustainable Development Goals
Citation
Lall, N, Kishore, N, Binneman, B, Twilley, D, Van de Venter, M, Plessis-Stoman, DD, Boukes, G & Hussein, A 2015, 'Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines', Natural Product Research, vol. 29, no. 18, pp. 1752-1756.