Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines
| dc.contributor.author | Lall, Namrita | |
| dc.contributor.author | Kishore, Navneet | |
| dc.contributor.author | Binneman, Brigitte | |
| dc.contributor.author | Twilley, Danielle | |
| dc.contributor.author | Van de Venter, Maryna | |
| dc.contributor.author | Du Plessis-Stoman, Debbie | |
| dc.contributor.author | Boukes, Gerhardt | |
| dc.contributor.author | Hussein, Ahmed A. | |
| dc.contributor.email | namrita.lall@up.ac.za | en_ZA |
| dc.date.accessioned | 2015-03-23T10:25:01Z | |
| dc.date.available | 2015-03-23T10:25:01Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | The present study was carried out to determine the cytotoxic effect of seven plant extracts and the isolated compounds; syringin and 4-methoxycinnamyl alcohol on cancerous and non-cancerous cells. The ethanol extract of F. vulgare was found to exhibit the most significant toxicity with an IC50 value of 19.97 μg/mL on HeLa cells. Bioassay guided fractionation lead to the isolation of two compounds, syringin (1) and 4-methoxycinnamyl alcohol (2). Both compounds showed toxicity against MCF-7, HeLa, and DU145 cancer cell line. The results showed that compound 2 showed high toxicity against all the cancer cell lines with IC50 values of 14.24, 7.82 and 22.10 μg/mL, respectively. 4-Methoxycinnamyl alcohol also showed no apoptotic effect in cell cycle analysis after 48 hours at a concentration of 10 μg/mL. However DNA fragmentation study revealed that, necrosis took place at a concentration of 10 μg/mL after 48 h exposure. | en_ZA |
| dc.description.embargo | 2016-09-15 | en_ZA |
| dc.description.librarian | hb2015 | en_ZA |
| dc.description.uri | http://www.tandfonline.com/loi/gnpl20 | en_ZA |
| dc.identifier.citation | Lall, N, Kishore, N, Binneman, B, Twilley, D, Van de Venter, M, Plessis-Stoman, DD, Boukes, G & Hussein, A 2015, 'Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines', Natural Product Research, vol. 29, no. 18, pp. 1752-1756. | en_ZA |
| dc.identifier.issn | 1478-6419 (print) | |
| dc.identifier.issn | 1478-6427 (online) | |
| dc.identifier.other | 10.1080/14786419.2014.999058 | |
| dc.identifier.uri | http://hdl.handle.net/2263/44108 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | Taylor and Francis | en_ZA |
| dc.rights | © Taylor and Francis. This is an electronic version of an article published in Natural Product Research, vol. 29, no. 18, pp. 1752-1756, 2015. doi : 10.1080/14786419.2014.999058. Natural Product Research is available online at : http://www.tandfonline.comloi/gnpl20. | en_ZA |
| dc.subject | Foeniculum vulgare | en_ZA |
| dc.subject | Cytotoxicity | en_ZA |
| dc.subject | 4-Methoxycinnamyl alcohol | en_ZA |
| dc.subject | Cell cycle analysis | en_ZA |
| dc.subject | DNA fragmentation | en_ZA |
| dc.title | Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines | en_ZA |
| dc.type | Postprint Article | en_ZA |