Identification of six new susceptibility loci for invasive epithelial ovarian cancer

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dc.contributor.author Kuchenbaecker, Karoline B.
dc.contributor.author Ramus, Susan J.
dc.contributor.author Tyrer, Jonathan
dc.contributor.author Lee, Andrew
dc.contributor.author Shen, Howard C.
dc.contributor.author Beesley, Jonathan
dc.contributor.author Lawrenson, Kate
dc.contributor.author McGuffog, Lesley
dc.contributor.author Healey, Sue
dc.contributor.author Lee, Janet M.
dc.contributor.author Spindler, Tassja J.
dc.contributor.author Lin, Yvonne G.
dc.contributor.author Pejovic, Tanja
dc.contributor.author Bean, Yukie
dc.contributor.author Li, Qiyuan
dc.contributor.author Coetzee, Simon
dc.contributor.author Hazelett, Dennis
dc.contributor.author Miron, Alexander
dc.contributor.author Southey, Melissa
dc.contributor.author Terry, Mary Beth
dc.contributor.author Goldgar, David E.
dc.contributor.author Buys, Saundra S.
dc.contributor.author Janavicius, Ramunas
dc.contributor.author Dorfling, Cecilia Maria
dc.contributor.author Van Rensburg, Elizabeth J.
dc.contributor.author Neuhausen, Susan L.
dc.contributor.author Ding, Yuan Chun
dc.contributor.author Hansen, Thomas V.O.
dc.contributor.author Jønson, Lars
dc.contributor.author Gerdes, Anne-Marie
dc.contributor.author Ejlertsen, Bent
dc.contributor.author Barrowdale, Daniel
dc.contributor.author Dennis, Joe
dc.contributor.author Benitez, Javier
dc.contributor.author Osorio, Ana
dc.contributor.author Garcia, Maria Jose
dc.contributor.author Komenaka, Ian
dc.contributor.author Weitzel, Jeffrey N.
dc.contributor.author Ganschow, Pamela
dc.contributor.author Peterlongo, Paolo
dc.contributor.author Bernard, Loris
dc.contributor.author Viel, Alessandra
dc.contributor.author Bonanni, Bernardo
dc.contributor.author Peissel, Bernard
dc.contributor.author Manoukian, Siranoush
dc.contributor.author Radice, Paolo
dc.contributor.author Papi, Laura
dc.contributor.author Ottini, Laura
dc.contributor.author Fostira, Florentia
dc.contributor.author Konstantopoulou, Irene
dc.contributor.author Garber, Judy
dc.contributor.author Frost, Debra
dc.contributor.author Perkins, Jo
dc.contributor.author Platte, Radka
dc.contributor.author Ellis, Steve
dc.contributor.author EMBRACE
dc.contributor.author Godwin, Andrew K.
dc.contributor.author Schmutzler, Rita Katharina
dc.contributor.author Meindl, Alfons
dc.contributor.author Engel, Christoph
dc.contributor.author Sutter, Christian
dc.contributor.author Sinilnikova, Olga M.
dc.contributor.author GEMO Study Collaborators
dc.contributor.author Damiola, Francesca
dc.contributor.author Mazoyer, Sylvie
dc.contributor.author Stoppa-Lyonnet, Dominique
dc.contributor.author Claes, Kathleen
dc.contributor.author De Leeneer, Kim
dc.contributor.author Kirk, Judy
dc.contributor.author Rodriguez, Gustavo C.
dc.contributor.author Piedmonte, Marion
dc.contributor.author O’Malley, David M.
dc.contributor.author De la Hoya, Miguel
dc.contributor.author Caldes, Trinidad
dc.contributor.author Aittomäki, Kristiina
dc.contributor.author Nevanlinna, Heli
dc.contributor.author Collée, J. Margriet
dc.contributor.author Rookus, Matti A.
dc.contributor.author Oosterwijk, Jan C.
dc.contributor.author Breast Cancer Family Registry
dc.contributor.author Tihomirova, Laima
dc.contributor.author Tung, Nadine
dc.contributor.author Hamann, Ute
dc.contributor.author Isaccs, Claudine
dc.contributor.author Tischkowitz, Marc
dc.contributor.author Imyanitov, Evgeny N.
dc.contributor.author Caligo, Maria A.
dc.contributor.author Campbell, Ian G.
dc.contributor.author Hogervorst, Frans B. L.
dc.contributor.author HEBON
dc.contributor.author Olah, Edith
dc.contributor.author Diez, Orland
dc.contributor.author Blanco, Ignacio
dc.contributor.author Brunet, Joan
dc.contributor.author Lazaro, Conxi
dc.contributor.author Pujana, Miquel Angel
dc.contributor.author Jakubowska, Anna
dc.contributor.author Gronwald, Jacek
dc.contributor.author Lubinski, Jan
dc.contributor.author Sukiennicki, Grzegorz
dc.contributor.author Barkardottir, Rosa B.
dc.contributor.author Plante, Marie
dc.contributor.author Simard, Jacques
dc.contributor.author Soucy, Penny
dc.contributor.author Montagna, Marco
dc.contributor.author Tognazzo, Silvia
dc.contributor.author Teixeira, Manuel R.
dc.contributor.author KConFab Investigators
dc.contributor.author Pankratz, Vernon S.
dc.contributor.author Wang, Xianshu
dc.contributor.author Lindor, Noralane
dc.contributor.author Szabo, Csilla I.
dc.contributor.author Kauff, Noah
dc.contributor.author Vijai, Joseph
dc.contributor.author Aghajanian, Carol A.
dc.contributor.author Pfeiler, Georg
dc.contributor.author Berger, Andreas
dc.contributor.author Singer, Christian F.
dc.contributor.author Tea, Muy-Kheng
dc.contributor.author Phelan, Catherine M.
dc.contributor.author Greene, Mark H.
dc.contributor.author Mai, Phuong L.
dc.contributor.author Rennert, Gad
dc.contributor.author Mulligan, Anna Marie
dc.contributor.author Tchatchou, Sandrine
dc.contributor.author Andrulis, Irene L.
dc.contributor.author Glendon, Gord
dc.contributor.author Toland, Amanda Ewart
dc.contributor.author Jensen, Uffe Birk
dc.contributor.author Kruse, Torben A.
dc.contributor.author Thomassen, Mads
dc.contributor.author Bojesen, Anders
dc.contributor.author Zidan, Jamal
dc.contributor.author Friedman, Eitan
dc.contributor.author Laitman, Yael
dc.contributor.author Soller, Maria
dc.contributor.author Liljegren, Annelie
dc.contributor.author Arver, Brita
dc.contributor.author Einbeigi, Zakaria
dc.contributor.author Stenmark-Askmalm, Marie
dc.contributor.author Olopade, Olufunmilayo I.
dc.contributor.author Nussbaum, Robert L.
dc.contributor.author Rebbeck, Timothy R.
dc.contributor.author Nathanson, Katherine L.
dc.contributor.author Domchek, Susan M.
dc.contributor.author Lu, Karen H.
dc.contributor.author Karlan, Beth Y.
dc.contributor.author Walsh, Christine
dc.contributor.author Lester, Jenny
dc.contributor.author Australian Cancer Study (Ovarian Cancer Investigators)
dc.contributor.author Australian Ovarian Cancer Study Group
dc.contributor.author Hein, Alexander
dc.contributor.author Ekici, Arif B.
dc.contributor.author Beckmann, Matthias W.
dc.contributor.author Fasching, Peter A.
dc.contributor.author Lambrechts, Diether
dc.contributor.author Van Nieuwenhuysen, Els
dc.contributor.author Vergote, Ignace
dc.contributor.author Lambrechts, Sandrina
dc.contributor.author Dicks, Ed
dc.contributor.author Doherty, Jennifer A.
dc.contributor.author Wicklund, Kristine G.
dc.contributor.author Rossing, Mary Anne
dc.contributor.author Rudolph, Anja
dc.contributor.author Chang-Claude, Jenny
dc.contributor.author Wang-Gohrke, Shan
dc.contributor.author Eilber, Ursula
dc.contributor.author Moysich, Kirsten B.
dc.contributor.author Odunsi, Kunle
dc.contributor.author Sucheston, Lara
dc.contributor.author Lele, Shashi
dc.contributor.author Wilkens, Lynne R.
dc.contributor.author Goodman, Marc T.
dc.contributor.author Thompson, Pamela J.
dc.contributor.author Shvetsov, Yurii B.
dc.contributor.author Runnebaum, Ingo B.
dc.contributor.author Dürst, Matthias
dc.contributor.author Hillemanns, Peter
dc.contributor.author Dörk, Thilo
dc.contributor.author Antonenkova, Natalia
dc.contributor.author Bogdanova, Natalia
dc.contributor.author Leminen, Arto
dc.contributor.author Pelttari, Liisa M.
dc.contributor.author Butzow, Ralf
dc.contributor.author Modugno, Francesmary
dc.contributor.author Kelley, Joseph L.
dc.contributor.author Edwards, Robert P.
dc.contributor.author Ness, Roberta B.
dc.contributor.author Du Bois, Andreas
dc.contributor.author Heitz, Florian
dc.contributor.author Schwaab, Ira
dc.contributor.author Harter, Philipp
dc.contributor.author Matsuo, Keitaro
dc.contributor.author Hosono, Satoyo
dc.contributor.author Orsulic, Sandra
dc.contributor.author Jensen, Allan
dc.contributor.author Kjaer, Susanne Kruger
dc.contributor.author Hogdall, Estrid
dc.contributor.author Hasmad, Hanis Nazihah
dc.contributor.author Azmi, Mat Adenan Noor
dc.contributor.author Teo, Soo-Hwang
dc.contributor.author Woo, Yin-Ling
dc.contributor.author Fridley, Brooke L.
dc.contributor.author Goode, Ellen L.
dc.contributor.author Cunningham, J.M. (Julie)
dc.contributor.author Vierkant, Robert A.
dc.contributor.author Bruinsma, Fiona
dc.contributor.author Giles, Graham G.
dc.contributor.author Liang, Dong
dc.contributor.author Hildebrandt, Michelle A.T.
dc.contributor.author Wu, Xifeng
dc.contributor.author Levine, Douglas A.
dc.contributor.author Bisogna, Maria
dc.contributor.author Berchuck, Andrew
dc.contributor.author Iversen, Edwin S.
dc.contributor.author Schildkraut, Joellen M.
dc.contributor.author Concannon, Patrick
dc.contributor.author Weber, Rachel Palmieri
dc.contributor.author Cramer, Daniel W.
dc.contributor.author Terry, Kathryn L.
dc.contributor.author Poole, Elizabeth M.
dc.contributor.author Tworoger, Shelley S.
dc.contributor.author Bandera, Elisa V.
dc.contributor.author Orlow, Irene
dc.contributor.author Olson, Sara H.
dc.contributor.author Krakstad, Camilla
dc.contributor.author Salvesen, Helga B.
dc.contributor.author Tangen, Ingvild L.
dc.contributor.author Bjorge, Line
dc.contributor.author Van Altena, Anne M.
dc.contributor.author Aben, Katja K.H.
dc.contributor.author Kiemeney, Lambertus A.
dc.contributor.author Massuger, Leon F.A.G.
dc.contributor.author Kellar, Melissa
dc.contributor.author Brooks-Wilson, Angela
dc.contributor.author Kelemen, Linda E.
dc.contributor.author Cook, Linda S.
dc.contributor.author Le, Nhu D.
dc.contributor.author Cybulski, Cezary
dc.contributor.author Yang, Hannah
dc.contributor.author Lissowska, Jolanta
dc.contributor.author Brinton, Louise A.
dc.contributor.author Wentzensen, Nicolas
dc.contributor.author Hogdall, Claus
dc.contributor.author Lundvall, Lene
dc.contributor.author Nedergaard, Lotte
dc.contributor.author Baker, Helen
dc.contributor.author Song, Honglin
dc.contributor.author Eccles, Diana M.
dc.contributor.author McNeish, Ian
dc.contributor.author Paul, James
dc.contributor.author Carty, Karen
dc.contributor.author Siddiqui, Nadeem
dc.contributor.author Glasspool, Rosalind
dc.contributor.author Whittemore, Alice S.
dc.contributor.author Rothstein, Joseph H.
dc.contributor.author McGuire, Valerie
dc.contributor.author Sieh, Weiva
dc.contributor.author Ji, Bu-Tian
dc.contributor.author Zheng, Wei
dc.contributor.author Shu, Xiao-Ou
dc.contributor.author Gao, Yu-Tang
dc.contributor.author Rosen, Barry
dc.contributor.author Risch, Harvey A.
dc.contributor.author McLaughlin, John R.
dc.contributor.author Narod, Steven A.
dc.contributor.author Monteiro, Alvaro N.
dc.contributor.author Chen, Ann
dc.contributor.author Lin, Hui-Yi
dc.contributor.author Permuth-Wey, Jenny
dc.contributor.author Sellers, Thomas A.
dc.contributor.author Tsai, Ya-Yu
dc.contributor.author Chen, Zhihua
dc.contributor.author Ziogas, Argyrios
dc.contributor.author Anton-Culver, Hoda
dc.contributor.author Gentry-Maharaj, Aleksandra
dc.contributor.author Menon, Usha
dc.contributor.author Harrington, Patricia
dc.contributor.author Lee, Alice W.
dc.contributor.author Wu, Anna H.
dc.contributor.author Pearce, Celeste L.
dc.contributor.author Coetzee, Gerry
dc.contributor.author Pike, Malcolm C.
dc.contributor.author Dansonka-Mieszkowska, Agnieszka
dc.contributor.author Timorek, Agnieszka
dc.contributor.author Rzepecka, Iwona K.
dc.contributor.author Kupryjanczyk, Jolanta
dc.contributor.author Freedman, Matt
dc.contributor.author Noushmehr, Houtan
dc.contributor.author Easton, Douglas F.
dc.contributor.author Offit, Kenneth
dc.contributor.author Couch, Fergus J.
dc.contributor.author Gayther, Simon
dc.contributor.author Pharoah, Paul P.
dc.contributor.author Antoniou, Antonis C.
dc.contributor.author Chenevix-Trench, Georgia
dc.contributor.author Consortium of Investigators of Modifiers of BRCA1
dc.contributor.author Consortium of Investigators of Modifiers of BRCA2
dc.date.accessioned 2015-03-20T05:34:16Z
dc.date.available 2015-03-20T05:34:16Z
dc.date.issued 2015-02
dc.description.abstract Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1 1000 Genomes Project data, we assessed associations of 11 11 11 11 million genetic variants with EOC risk from 1 15,437 cases unselected for family history and 30,845 controls and from 1 15,252 BRCA1 mutation carriers and 8,211 11 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 1 17q1111.2 (ATAD5) were associated with EOC risk, and at 1 1p34.3 (RSPO1) and 6p22.1 1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 1 10−8. Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.uri http://www.nature.com en_ZA
dc.identifier.citation Kuchenbaecker, KB, Ramus, SJ, Tyrer, J, Lee, A et al. 2015, 'Identification of six new susceptibility loci for invasive epithelial ovarian cancer', Nature genetics, vol. 47, no. 2, pp. 164-171. en_ZA
dc.identifier.issn 1061-4036 (print)
dc.identifier.issn 1546-1718 (online)
dc.identifier.other 10.1038/ng.3185
dc.identifier.uri http://hdl.handle.net/2263/44069
dc.language.iso en en_ZA
dc.publisher Nature Publishing Group en_ZA
dc.rights © 2015 Macmillan Publishers Limited. All Rights Reserved en_ZA
dc.subject Genetic factors en_ZA
dc.subject Disease susceptibility en_ZA
dc.subject Invasive en_ZA
dc.subject Epithelial ovarian cancer (EOC) en_ZA
dc.title Identification of six new susceptibility loci for invasive epithelial ovarian cancer en_ZA
dc.type Postprint Article en_ZA


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