Identification of six new susceptibility loci for invasive epithelial ovarian cancer

dc.contributor.authorKuchenbaecker, Karoline B.
dc.contributor.authorRamus, Susan J.
dc.contributor.authorTyrer, Jonathan
dc.contributor.authorLee, Andrew
dc.contributor.authorShen, Howard C.
dc.contributor.authorBeesley, Jonathan
dc.contributor.authorLawrenson, Kate
dc.contributor.authorMcGuffog, Lesley
dc.contributor.authorHealey, Sue
dc.contributor.authorLee, Janet M.
dc.contributor.authorSpindler, Tassja J.
dc.contributor.authorLin, Yvonne G.
dc.contributor.authorPejovic, Tanja
dc.contributor.authorBean, Yukie
dc.contributor.authorLi, Qiyuan
dc.contributor.authorCoetzee, Simon
dc.contributor.authorHazelett, Dennis
dc.contributor.authorMiron, Alexander
dc.contributor.authorSouthey, Melissa
dc.contributor.authorTerry, Mary Beth
dc.contributor.authorGoldgar, David E.
dc.contributor.authorBuys, Saundra S.
dc.contributor.authorJanavicius, Ramunas
dc.contributor.authorDorfling, Cecilia Maria
dc.contributor.authorJansen van Rensburg, Elizabeth
dc.contributor.authorNeuhausen, Susan L.
dc.contributor.authorDing, Yuan Chun
dc.contributor.authorHansen, Thomas V.O.
dc.contributor.authorJønson, Lars
dc.contributor.authorGerdes, Anne-Marie
dc.contributor.authorEjlertsen, Bent
dc.contributor.authorBarrowdale, Daniel
dc.contributor.authorDennis, Joe
dc.contributor.authorBenitez, Javier
dc.contributor.authorOsorio, Ana
dc.contributor.authorGarcia, Maria Jose
dc.contributor.authorKomenaka, Ian
dc.contributor.authorWeitzel, Jeffrey N.
dc.contributor.authorGanschow, Pamela
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorBernard, Loris
dc.contributor.authorViel, Alessandra
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorPeissel, Bernard
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorRadice, Paolo
dc.contributor.authorPapi, Laura
dc.contributor.authorOttini, Laura
dc.contributor.authorFostira, Florentia
dc.contributor.authorKonstantopoulou, Irene
dc.contributor.authorGarber, Judy
dc.contributor.authorFrost, Debra
dc.contributor.authorPerkins, Jo
dc.contributor.authorPlatte, Radka
dc.contributor.authorEllis, Steve
dc.contributor.authorEMBRACE
dc.contributor.authorGodwin, Andrew K.
dc.contributor.authorSchmutzler, Rita Katharina
dc.contributor.authorMeindl, Alfons
dc.contributor.authorEngel, Christoph
dc.contributor.authorSutter, Christian
dc.contributor.authorSinilnikova, Olga M.
dc.contributor.authorGEMO Study Collaborators
dc.contributor.authorDamiola, Francesca
dc.contributor.authorMazoyer, Sylvie
dc.contributor.authorStoppa-Lyonnet, Dominique
dc.contributor.authorClaes, Kathleen
dc.contributor.authorDe Leeneer, Kim
dc.contributor.authorKirk, Judy
dc.contributor.authorRodriguez, Gustavo C.
dc.contributor.authorPiedmonte, Marion
dc.contributor.authorO’Malley, David M.
dc.contributor.authorDe la Hoya, Miguel
dc.contributor.authorCaldes, Trinidad
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorCollée, J. Margriet
dc.contributor.authorRookus, Matti A.
dc.contributor.authorOosterwijk, Jan C.
dc.contributor.authorBreast Cancer Family Registry
dc.contributor.authorTihomirova, Laima
dc.contributor.authorTung, Nadine
dc.contributor.authorHamann, Ute
dc.contributor.authorIsaccs, Claudine
dc.contributor.authorTischkowitz, Marc
dc.contributor.authorImyanitov, Evgeny N.
dc.contributor.authorCaligo, Maria A.
dc.contributor.authorCampbell, Ian G.
dc.contributor.authorHogervorst, Frans B. L.
dc.contributor.authorHEBON
dc.contributor.authorOlah, Edith
dc.contributor.authorDiez, Orland
dc.contributor.authorBlanco, Ignacio
dc.contributor.authorBrunet, Joan
dc.contributor.authorLazaro, Conxi
dc.contributor.authorPujana, Miquel Angel
dc.contributor.authorJakubowska, Anna
dc.contributor.authorGronwald, Jacek
dc.contributor.authorLubinski, Jan
dc.contributor.authorSukiennicki, Grzegorz
dc.contributor.authorBarkardottir, Rosa B.
dc.contributor.authorPlante, Marie
dc.contributor.authorSimard, Jacques
dc.contributor.authorSoucy, Penny
dc.contributor.authorMontagna, Marco
dc.contributor.authorTognazzo, Silvia
dc.contributor.authorTeixeira, Manuel R.
dc.contributor.authorKConFab Investigators
dc.contributor.authorPankratz, Vernon S.
dc.contributor.authorWang, Xianshu
dc.contributor.authorLindor, Noralane
dc.contributor.authorSzabo, Csilla I.
dc.contributor.authorKauff, Noah
dc.contributor.authorVijai, Joseph
dc.contributor.authorAghajanian, Carol A.
dc.contributor.authorPfeiler, Georg
dc.contributor.authorBerger, Andreas
dc.contributor.authorSinger, Christian F.
dc.contributor.authorTea, Muy-Kheng
dc.contributor.authorPhelan, Catherine M.
dc.contributor.authorGreene, Mark H.
dc.contributor.authorMai, Phuong L.
dc.contributor.authorRennert, Gad
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorTchatchou, Sandrine
dc.contributor.authorAndrulis, Irene L.
dc.contributor.authorGlendon, Gord
dc.contributor.authorToland, Amanda Ewart
dc.contributor.authorJensen, Uffe Birk
dc.contributor.authorKruse, Torben A.
dc.contributor.authorThomassen, Mads
dc.contributor.authorBojesen, Anders
dc.contributor.authorZidan, Jamal
dc.contributor.authorFriedman, Eitan
dc.contributor.authorLaitman, Yael
dc.contributor.authorSoller, Maria
dc.contributor.authorLiljegren, Annelie
dc.contributor.authorArver, Brita
dc.contributor.authorEinbeigi, Zakaria
dc.contributor.authorStenmark-Askmalm, Marie
dc.contributor.authorOlopade, Olufunmilayo I.
dc.contributor.authorNussbaum, Robert L.
dc.contributor.authorRebbeck, Timothy R.
dc.contributor.authorNathanson, Katherine L.
dc.contributor.authorDomchek, Susan M.
dc.contributor.authorLu, Karen H.
dc.contributor.authorKarlan, Beth Y.
dc.contributor.authorWalsh, Christine
dc.contributor.authorLester, Jenny
dc.contributor.authorAustralian Cancer Study (Ovarian Cancer Investigators)
dc.contributor.authorAustralian Ovarian Cancer Study Group
dc.contributor.authorHein, Alexander
dc.contributor.authorEkici, Arif B.
dc.contributor.authorBeckmann, Matthias W.
dc.contributor.authorFasching, Peter A.
dc.contributor.authorLambrechts, Diether
dc.contributor.authorVan Nieuwenhuysen, Els
dc.contributor.authorVergote, Ignace
dc.contributor.authorLambrechts, Sandrina
dc.contributor.authorDicks, Ed
dc.contributor.authorDoherty, Jennifer A.
dc.contributor.authorWicklund, Kristine G.
dc.contributor.authorRossing, Mary Anne
dc.contributor.authorRudolph, Anja
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorWang-Gohrke, Shan
dc.contributor.authorEilber, Ursula
dc.contributor.authorMoysich, Kirsten B.
dc.contributor.authorOdunsi, Kunle
dc.contributor.authorSucheston, Lara
dc.contributor.authorLele, Shashi
dc.contributor.authorWilkens, Lynne R.
dc.contributor.authorGoodman, Marc T.
dc.contributor.authorThompson, Pamela J.
dc.contributor.authorShvetsov, Yurii B.
dc.contributor.authorRunnebaum, Ingo B.
dc.contributor.authorDürst, Matthias
dc.contributor.authorHillemanns, Peter
dc.contributor.authorDörk, Thilo
dc.contributor.authorAntonenkova, Natalia
dc.contributor.authorBogdanova, Natalia
dc.contributor.authorLeminen, Arto
dc.contributor.authorPelttari, Liisa M.
dc.contributor.authorButzow, Ralf
dc.contributor.authorModugno, Francesmary
dc.contributor.authorKelley, Joseph L.
dc.contributor.authorEdwards, Robert P.
dc.contributor.authorNess, Roberta B.
dc.contributor.authorDu Bois, Andreas
dc.contributor.authorHeitz, Florian
dc.contributor.authorSchwaab, Ira
dc.contributor.authorHarter, Philipp
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorHosono, Satoyo
dc.contributor.authorOrsulic, Sandra
dc.contributor.authorJensen, Allan
dc.contributor.authorKjaer, Susanne Kruger
dc.contributor.authorHogdall, Estrid
dc.contributor.authorHasmad, Hanis Nazihah
dc.contributor.authorAzmi, Mat Adenan Noor
dc.contributor.authorTeo, Soo-Hwang
dc.contributor.authorWoo, Yin-Ling
dc.contributor.authorFridley, Brooke L.
dc.contributor.authorGoode, Ellen L.
dc.contributor.authorCunningham, Julie M.
dc.contributor.authorVierkant, Robert A.
dc.contributor.authorBruinsma, Fiona
dc.contributor.authorGiles, Graham G.
dc.contributor.authorLiang, Dong
dc.contributor.authorHildebrandt, Michelle A.T.
dc.contributor.authorWu, Xifeng
dc.contributor.authorLevine, Douglas A.
dc.contributor.authorBisogna, Maria
dc.contributor.authorBerchuck, Andrew
dc.contributor.authorIversen, Edwin S.
dc.contributor.authorSchildkraut, Joellen M.
dc.contributor.authorConcannon, Patrick
dc.contributor.authorWeber, Rachel Palmieri
dc.contributor.authorCramer, Daniel W.
dc.contributor.authorTerry, Kathryn L.
dc.contributor.authorPoole, Elizabeth M.
dc.contributor.authorTworoger, Shelley S.
dc.contributor.authorBandera, Elisa V.
dc.contributor.authorOrlow, Irene
dc.contributor.authorOlson, Sara H.
dc.contributor.authorKrakstad, Camilla
dc.contributor.authorSalvesen, Helga B.
dc.contributor.authorTangen, Ingvild L.
dc.contributor.authorBjorge, Line
dc.contributor.authorVan Altena, Anne M.
dc.contributor.authorAben, Katja K.H.
dc.contributor.authorKiemeney, Lambertus A.
dc.contributor.authorMassuger, Leon F.A.G.
dc.contributor.authorKellar, Melissa
dc.contributor.authorBrooks-Wilson, Angela
dc.contributor.authorKelemen, Linda E.
dc.contributor.authorCook, Linda S.
dc.contributor.authorLe, Nhu D.
dc.contributor.authorCybulski, Cezary
dc.contributor.authorYang, Hannah
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorBrinton, Louise A.
dc.contributor.authorWentzensen, Nicolas
dc.contributor.authorHogdall, Claus
dc.contributor.authorLundvall, Lene
dc.contributor.authorNedergaard, Lotte
dc.contributor.authorBaker, Helen
dc.contributor.authorSong, Honglin
dc.contributor.authorEccles, Diana M.
dc.contributor.authorMcNeish, Ian
dc.contributor.authorPaul, James
dc.contributor.authorCarty, Karen
dc.contributor.authorSiddiqui, Nadeem
dc.contributor.authorGlasspool, Rosalind
dc.contributor.authorWhittemore, Alice S.
dc.contributor.authorRothstein, Joseph H.
dc.contributor.authorMcGuire, Valerie
dc.contributor.authorSieh, Weiva
dc.contributor.authorJi, Bu-Tian
dc.contributor.authorZheng, Wei
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorRosen, Barry
dc.contributor.authorRisch, Harvey A.
dc.contributor.authorMcLaughlin, John R.
dc.contributor.authorNarod, Steven A.
dc.contributor.authorMonteiro, Alvaro N.
dc.contributor.authorChen, Ann
dc.contributor.authorLin, Hui-Yi
dc.contributor.authorPermuth-Wey, Jenny
dc.contributor.authorSellers, Thomas A.
dc.contributor.authorTsai, Ya-Yu
dc.contributor.authorChen, Zhihua
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorGentry-Maharaj, Aleksandra
dc.contributor.authorMenon, Usha
dc.contributor.authorHarrington, Patricia
dc.contributor.authorLee, Alice W.
dc.contributor.authorWu, Anna H.
dc.contributor.authorPearce, Celeste L.
dc.contributor.authorCoetzee, Gerry
dc.contributor.authorPike, Malcolm C.
dc.contributor.authorDansonka-Mieszkowska, Agnieszka
dc.contributor.authorTimorek, Agnieszka
dc.contributor.authorRzepecka, Iwona K.
dc.contributor.authorKupryjanczyk, Jolanta
dc.contributor.authorFreedman, Matt
dc.contributor.authorNoushmehr, Houtan
dc.contributor.authorEaston, Douglas F.
dc.contributor.authorOffit, Kenneth
dc.contributor.authorCouch, Fergus J.
dc.contributor.authorGayther, Simon
dc.contributor.authorPharoah, Paul P.
dc.contributor.authorAntoniou, Antonis C.
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorConsortium of Investigators of Modifiers of BRCA1
dc.contributor.authorConsortium of Investigators of Modifiers of BRCA2
dc.date.accessioned2015-03-20T05:34:16Z
dc.date.available2015-03-20T05:34:16Z
dc.date.issued2015-02
dc.description.abstractGenome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1 1000 Genomes Project data, we assessed associations of 11 11 11 11 million genetic variants with EOC risk from 1 15,437 cases unselected for family history and 30,845 controls and from 1 15,252 BRCA1 mutation carriers and 8,211 11 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 1 17q1111.2 (ATAD5) were associated with EOC risk, and at 1 1p34.3 (RSPO1) and 6p22.1 1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 1 10−8. Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.en_ZA
dc.description.librarianhb2015en_ZA
dc.description.urihttp://www.nature.comen_ZA
dc.identifier.citationKuchenbaecker, KB, Ramus, SJ, Tyrer, J, Lee, A et al. 2015, 'Identification of six new susceptibility loci for invasive epithelial ovarian cancer', Nature genetics, vol. 47, no. 2, pp. 164-171.en_ZA
dc.identifier.issn1061-4036 (print)
dc.identifier.issn1546-1718 (online)
dc.identifier.other10.1038/ng.3185
dc.identifier.urihttp://hdl.handle.net/2263/44069
dc.language.isoenen_ZA
dc.publisherNature Publishing Groupen_ZA
dc.rights© 2015 Macmillan Publishers Limited. All Rights Reserveden_ZA
dc.subjectGenetic factorsen_ZA
dc.subjectDisease susceptibilityen_ZA
dc.subjectInvasiveen_ZA
dc.subjectEpithelial ovarian cancer (EOC)en_ZA
dc.titleIdentification of six new susceptibility loci for invasive epithelial ovarian canceren_ZA
dc.typePostprint Articleen_ZA

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