Non-IgE-mediated food allergies
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Date
Authors
Terblanche, Alta J.
Lang, A.C.
Gray, Claudia L.
Goddard, E.
Karabus, S.
Kriel, M.
Manjra, Ahmed I.
Risenga, Samuel Malamulele
Van der Spuy, D.A.
Levin, M.E.
Journal Title
Journal ISSN
Volume Title
Publisher
Health and Medical Publishing Group
Abstract
Non-imunoglobulin E (IgE)-mediated conditions include combined IgE and cell-mediated conditions such as atopic dermatitis and
eosinophilic oesophagitis, and pure T-cell-mediated conditions such as food protein-induced enterocolitis syndrome, allergic proctocolitis
and enteropathy syndromes.
Diagnosing mixed or non-IgE-mediated allergy is challenging. A clear cause-effect relationship between exposure to the suspected food
and symptoms is not always possible, as symptoms develop over time and are more chronic in nature. Skin-prick tests and specific IgE to
the allergen are usually negative. An elimination diet may be necessary to diagnose non-IgE-mediated type food allergy. The suspected
allergen should be excluded from the diet for 2 - 6 weeks under dietetic guidance to assess for improvement of symptoms. After symptom
improvement, a rechallenge is necessary to definitively prove causal relation.
Description
Keywords
Food allergies, Non-imunoglobulin E (IgE), Non-IgE-mediated food allergy, Eosinophilic oesophagitis (EoE), Atopic dermatitis (AD), Food protein-induced enterocolitis syndrome (FPIES), Food protein-induced allergic proctocolitis, Eosinophilic gastroenteritis (EG)
Sustainable Development Goals
Citation
Terblanche, AJ, Lang, AC, Gray, CL, Goddard, E, Karabus, S, Kriel, M, Manjra, AI, Risenga, SM, Van der Spuy, DA & Levin, ME 2015, 'Non-IgE-mediated food allergies', South African Medical Journal, vol. 105, no. 1, pp. 66.