Non-IgE-mediated food allergies

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Authors

Terblanche, Alta J.
Lang, A.C.
Gray, Claudia L.
Goddard, E.
Karabus, S.
Kriel, M.
Manjra, Ahmed I.
Risenga, Samuel Malamulele
Van der Spuy, D.A.
Levin, M.E.

Journal Title

Journal ISSN

Volume Title

Publisher

Health and Medical Publishing Group

Abstract

Non-imunoglobulin E (IgE)-mediated conditions include combined IgE and cell-mediated conditions such as atopic dermatitis and eosinophilic oesophagitis, and pure T-cell-mediated conditions such as food protein-induced enterocolitis syndrome, allergic proctocolitis and enteropathy syndromes. Diagnosing mixed or non-IgE-mediated allergy is challenging. A clear cause-effect relationship between exposure to the suspected food and symptoms is not always possible, as symptoms develop over time and are more chronic in nature. Skin-prick tests and specific IgE to the allergen are usually negative. An elimination diet may be necessary to diagnose non-IgE-mediated type food allergy. The suspected allergen should be excluded from the diet for 2 - 6 weeks under dietetic guidance to assess for improvement of symptoms. After symptom improvement, a rechallenge is necessary to definitively prove causal relation.

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Keywords

Food allergies, Non-imunoglobulin E (IgE), Non-IgE-mediated food allergy, Eosinophilic oesophagitis (EoE), Atopic dermatitis (AD), Food protein-induced enterocolitis syndrome (FPIES), Food protein-induced allergic proctocolitis, Eosinophilic gastroenteritis (EG)

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Citation

Terblanche, AJ, Lang, AC, Gray, CL, Goddard, E, Karabus, S, Kriel, M, Manjra, AI, Risenga, SM, Van der Spuy, DA & Levin, ME 2015, 'Non-IgE-mediated food allergies', South African Medical Journal, vol. 105, no. 1, pp. 66.