Retinoblastoma outcome at a single institution in South Africa

Show simple item record Kruger, Mariana Reynders, David Omar, Fareed E. Schoeman, Judy Wedi, Opope Oyaka Harvey, J. 2015-02-12T12:57:26Z 2015-02-12T12:57:26Z 2014-12
dc.description.abstract INTRODUCTION : Retinoblastoma (RB) is the most common eye cancer in children. Early detection is necessary for cure. OBJECTVE : To compare stage and outcome of children with RB treated at Kalafong Hospital, Pretoria, South Africa (SA), during two time periods (1993 - 2000 and 2001 - 2008, after outreach interventions in 2000 and introduction of compulsory community service for doctors in 1998). METHODS : Data collected included demography (age, gender, date of birth), stage and treatment received. The main outcome measure was disease-free survival and the study end-point was 60 months after diagnosis. RESULTS : There were 51 patients during the time period 1993 - 2000 (group 1) and 73 during 2001 - 2008 (group 2), with median ages of 32 and 26 months, respectively (marginally significantly younger in group 2; p=0.046). In group 1, the majority (57%) presented with advanced disease (stages III and IV), with a decline in this proportion in group 2 (40%) indicating a downward but not significant trend (p=0.075). Bilateral disease was diagnosed in 22% of patients in group 1 and 33% in group 2. Overall survival was 33% and 43% for groups 1 and 2, respectively. Excluding absconding patients, event-free survival was 50% in group 1, improving to 68% in group 2 (not statistically significant; p=0.18). Fewer patients needed radiotherapy during the second period (statistically significant; p=0.04), probably because of less advanced disease. CONCLUSION : Poor outcome is probably a result of late diagnosis. It is important to implement a strategy that will ensure early diagnosis and optimal management of RB in SA. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Kruger, M, Reynders, D, Omar, F, Schoemna, J, Wedi, O & Harvey, J 2014, 'Retinoblastoma outcome at a single institution in South Africa', South African Medical Journal, vol. 104, no. 12, pp. 859-863. en_ZA
dc.identifier.issn 0256-9574 (print)
dc.identifier.issn 2078-5135 (online)
dc.identifier.other 10.7196/SAMJ.8255
dc.language.iso en en_ZA
dc.publisher South African Medical Journal en_ZA
dc.rights © 2014 Health & Medical Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial Works License (CC BY-NC 3.0). en_ZA
dc.subject Retinoblastoma (RB) en_ZA
dc.subject Eye cancer in children en_ZA
dc.subject South Africa (SA) en_ZA
dc.title Retinoblastoma outcome at a single institution in South Africa en_ZA
dc.type Article en_ZA

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