The effect of sibutramine, a serotonin-norepinephrine reuptake inhibitor, on platelets and fibrin networks of male Sprague-Dawley rats : a descriptive study

Show simple item record

dc.contributor.author Van der Schoor, Ciska
dc.contributor.author Oberholzer, Hester Magdalena
dc.contributor.author Bester, Megan Jean
dc.contributor.author Van Rooy, Mia-Jeanne
dc.date.accessioned 2015-01-28T06:26:53Z
dc.date.available 2015-01-28T06:26:53Z
dc.date.issued 2014-12
dc.description.abstract Sibutramine is used in the treatment of obesity due to its ability to influence feelings of hunger and satiety by inhibiting the re-uptake of serotonin and noradrenalin in the central nervous system (CNS). Sibutramine use has been associated with numerous adverse events in particular cardiovascular complications possibly due to the formation of thrombi. This ultrastructural descriptive study investigated the effect of sibutramine on blood coagulation, specifically the effect on morphology of platelets and fibrin networks using scanning electron microscopy. Male Sprague–Dawley rats treated with either a recommended therapeutic dose [low dosage 1.32 mg/kg] or a toxicological higher dose [high dosage 13.2 mg/kg] of sibutramine for 28 days were used and compared to control animals. Blood samples were collected and plasma smears were prepared for platelet evaluation. Following the addition of thrombin to the plasma samples, the morphology of the fibrin clots was evaluated. Platelet evaluation by scanning electron microscopy revealed morphology typical of a prothrombotic state with a characteristic excessive platelet activation in both low-dose (LD) and high-dose (HD) rats. The fibrin clots of sibutramine-treated rats, LD and HD revealed fused thick fibers with thin fibers forming a netlike structure over the thick fibers which differ considerably from the organized structure of the control animals. It can be concluded that sibutramine alters the ultrastructure of platelets and fibrin networks creating a prothrombotic state. en_ZA
dc.description.embargo 2015-12-30 en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.uri http://informahealthcare.com/journal/usp en_ZA
dc.identifier.citation Van der Schoor, C, Oberholzer, HM, Bester, MJ & Van Rooy, MJ 2014, 'The effect of sibutramine, a serotonin-norepinephrine reuptake inhibitor, on platelets and fibrin networks of male Sprague-Dawley rats : a descriptive study', Ultrastructural Pathology, vol. 38, no. 6, pp. 399-405. en_ZA
dc.identifier.issn 0191-3123 (print)
dc.identifier.issn 1521-0758 (online)
dc.identifier.other 10.3109/01913123.2014.946635
dc.identifier.uri http://hdl.handle.net/2263/43459
dc.language.iso en en_ZA
dc.publisher Informa Healthcare en_ZA
dc.rights © Informa Healthcare USA Inc. This is an electronic version of an article published in Ultrastructural Pathology, vol. 38, no. 6, pp. 399-405, 2014. doi :10.3109/01913123.2014.946635. Ultrastructural Pathology is available online at : http://informahealthcare.com/journal/usp en_ZA
dc.subject Fibrin networks en_ZA
dc.subject Plasma en_ZA
dc.subject Platelets en_ZA
dc.subject Prothrombotic state en_ZA
dc.subject Sibutramine en_ZA
dc.title The effect of sibutramine, a serotonin-norepinephrine reuptake inhibitor, on platelets and fibrin networks of male Sprague-Dawley rats : a descriptive study en_ZA
dc.type Postprint Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record