Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro

Anderson, Ronald; Steel, Helen C.; Cockeran, Riana; Von Gottberg, Anne; De Gouveia, L.; Klugman, Keith P.; Mitchell, Timothy J.; Feldman, Charles

dc.contributor.author	Anderson, Ronald
dc.contributor.author	Steel, Helen C.
dc.contributor.author	Cockeran, Riana
dc.contributor.author	Von Gottberg, Anne
dc.contributor.author	De Gouveia, L.
dc.contributor.author	Klugman, Keith P.
dc.contributor.author	Mitchell, Timothy J.
dc.contributor.author	Feldman, Charles
dc.date.accessioned	2008-01-31T12:53:08Z
dc.date.available	2008-01-31T12:53:08Z
dc.date.issued	2007-11
dc.description.abstract	OBJECTIVES: To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline on pneumolysin production by a macrolide-susceptible strain and two macrolide-resistant strains [erm(B) or mef(A)] of Streptococcus pneumoniae. METHODS: Please refer to abstract in article. RESULTS: Only the macrolides/macrolide-like agents caused significant attenuation of the production of pneumolysin, which was evident with all three strains of the pneumococcus. CONCLUSIONS: Macrolides, at sub-MICs, but not other classes of antibiotic, subvert the production of pneumolysin, even in the presence of (and irrespective of the mechanism of) macrolide resistance in S. pneumoniae.	en
dc.description.sponsorship	The study was supported in part by a grant awarded to R. C. by the National Health Laboratory Service of South Africa Research Trust. R. A. has received a research grant from Abbott Laboratories in partial support of the current study.	en
dc.format.extent	124477 bytes
dc.format.mimetype	application/pdf
dc.identifier.citation	Anderson, R, Steel, HC, Cockeran, R, Von Gottberg, A, De Gouveia, L, Klugman, KP, Mitchell, TJ & Feldman, C 2007, 'Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro', Journal of Antimicrobial Chemotherapy, vol. 60, no. 5, pp. 1155-1158. [http://jac.oxfordjournals.org]	en
dc.identifier.issn	1460-2091
dc.identifier.other	10.1093/jac/dkm338
dc.identifier.uri	http://hdl.handle.net/2263/4329
dc.language.iso	en	en
dc.publisher	Oxford University Press	en
dc.rights	Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Antimicrobial Chemotherapy following peer review. The definitive publisher-authenticated version is available online at: http://jac.oxfordjournals.org/cgi/content/full/60/5/1155.	en
dc.subject	Macrolide resistance	en
dc.subject	Pneumococcus	en
dc.subject	Protein synthesis	en
dc.subject.lcsh	Antibacterial agents -- Research
dc.subject.lcsh	Drug resistance in microorganisms -- Genetic aspects
dc.title	Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro	en
dc.type	Postprint Article	en