Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro
| dc.contributor.author | Anderson, Ronald | |
| dc.contributor.author | Steel, Helen Carolyn | |
| dc.contributor.author | Cockeran, Riana | |
| dc.contributor.author | Von Gottberg, Anne | |
| dc.contributor.author | De Gouveia, L. | |
| dc.contributor.author | Klugman, Keith P. | |
| dc.contributor.author | Mitchell, Timothy J. | |
| dc.contributor.author | Feldman, Charles | |
| dc.contributor.email | ronald.anderson@up.ac.za | en |
| dc.date.accessioned | 2008-01-31T12:53:08Z | |
| dc.date.available | 2008-01-31T12:53:08Z | |
| dc.date.issued | 2007-11 | |
| dc.description.abstract | OBJECTIVES: To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline on pneumolysin production by a macrolide-susceptible strain and two macrolide-resistant strains [erm(B) or mef(A)] of Streptococcus pneumoniae. METHODS: Please refer to abstract in article. RESULTS: Only the macrolides/macrolide-like agents caused significant attenuation of the production of pneumolysin, which was evident with all three strains of the pneumococcus. CONCLUSIONS: Macrolides, at sub-MICs, but not other classes of antibiotic, subvert the production of pneumolysin, even in the presence of (and irrespective of the mechanism of) macrolide resistance in S. pneumoniae. | en |
| dc.description.sponsorship | The study was supported in part by a grant awarded to R. C. by the National Health Laboratory Service of South Africa Research Trust. R. A. has received a research grant from Abbott Laboratories in partial support of the current study. | en |
| dc.format.extent | 124477 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.citation | Anderson, R, Steel, HC, Cockeran, R, Von Gottberg, A, De Gouveia, L, Klugman, KP, Mitchell, TJ & Feldman, C 2007, 'Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro', Journal of Antimicrobial Chemotherapy, vol. 60, no. 5, pp. 1155-1158. [http://jac.oxfordjournals.org] | en |
| dc.identifier.issn | 1460-2091 | |
| dc.identifier.other | 10.1093/jac/dkm338 | |
| dc.identifier.uri | http://hdl.handle.net/2263/4329 | |
| dc.language.iso | en | en |
| dc.publisher | Oxford University Press | en |
| dc.rights | Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Antimicrobial Chemotherapy following peer review. The definitive publisher-authenticated version is available online at: http://jac.oxfordjournals.org/cgi/content/full/60/5/1155. | en |
| dc.subject | Macrolide resistance | en |
| dc.subject | Pneumococcus | en |
| dc.subject | Protein synthesis | en |
| dc.subject.lcsh | Antibacterial agents -- Research | |
| dc.subject.lcsh | Drug resistance in microorganisms -- Genetic aspects | |
| dc.title | Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro | en |
| dc.type | Postprint Article | en |