Cardiac glycoside poisoning in sheep caused by Urginea physodes (Jacq.) Bak. and the isolated physodine A
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Date
Authors
Nel, P.W.
Jordaan, P.
Anderson, L.A.P.
Kellerman, T. Stephanus
Reid, Clare
Schultz, R.A. (Rowena Anitra)
Journal Title
Journal ISSN
Volume Title
Publisher
Published by the Government Printer, Pretoria.
Abstract
Urginea physodes (Jacq.) Bak., a species closely related to or possibly synonymous with U. pusilla, is described and its distribution given. Four bufadienolides were isolated from U. physodes and the approximated LD₅₀ and cumulative effect of some of them determined in guinea pigs. The most toxic one proved to be mildly cumulative. Typical signs of acute cardiac glycoside poisoning, involving the locomotory, gastro-intestinal, respiratory and cardiac systems, were seen in the field cases and/or were experimentally induced by the plant. Similar signs could also be induced by injecting the isolated bufadienolide, physodine A, to a sheep.
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Keywords
Veterinary medicine
Sustainable Development Goals
Citation
Nel, PW, Schultz, RA, Jordaan, P, Anderson, LAP, Kellerman, TS & Reid, C 1987, 'Cardiac glycoside poisoning in sheep caused by Urginea physodes (Jacq.) Bak. and the isolated physodine A’, Onderstepoort Journal of Veterinary Research, vol. 54, no. 4, pp. 641-644.