Aetiopathogenesis of atopic dermatitis

Show simple item record Jordaan, H.F. Todd, G. Sinclair, Werner Green, Robin J. 2014-10-22T08:29:11Z 2014-10-22T08:29:11Z 2014-10
dc.description.abstract The aetiopathogenesis of atopic dermatitis (AD) is complex and during recent years much has been learnt regarding the genetic predisposition to the development of this condition and how its interaction with the environment influences clinical manifestations. AD is not a simple allergic condition. An inherited stratum corneum barrier defect, transepidermal water loss, early antigen exposure through the skin and over-hygienic care of the young child seem to be the major drivers in the manifestation of the disease. Many other, more specific, environmental factors may influence the clinical picture in individual patients; some of these have an allergic basis, while others do not. In this article, the terminology used in this issue of CME is explained, the evidence for the different aetiopathological factors is presented and the factors that worsen or improve AD are listed. en_US
dc.description.librarian am2014 en_US
dc.description.uri en_US
dc.identifier.citation Jordaan, HF, Todd, G, Sinclair, W & Green, RJ 2014, 'Aetiopathogenesis of atopic dermatitis', South African Medical Journal, vol. 104, no. 10, pp. 706-709. en_US
dc.identifier.issn 0256-9574 (print)
dc.identifier.issn 2078-5135 (online)
dc.identifier.other 10.7196/SAMJ.8840
dc.language.iso en en_US
dc.publisher Health and Medical Publishing Group en_US
dc.rights Health and Medical Publishing Group en_US
dc.subject Aetiopathogenesis en_US
dc.subject Atopic dermatitis (AD) en_US
dc.subject Genetics en_US
dc.subject Allergic sensitisation en_US
dc.subject Environment en_US
dc.subject Food allergy en_US
dc.title Aetiopathogenesis of atopic dermatitis en_US
dc.type Article en_US

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