Inflammation and cancer : the role of the human neutrophil

Show simple item record Anderson, Ronald Tintinger, Gregory Ronald Feldman, Charles 2014-06-06T09:29:34Z 2014-06-06T09:29:34Z 2014-01
dc.description.abstract Chronic inflammation of both infective and non-infective origin has been implicated in the aetiology of approximately 30% of all human epithelial malignancies. The primary carcinogens are reactive oxygen species (ROS) derived from activated, infiltrating cells of the innate immune system, especially neutrophils, which inflict oxidative damage on the DNA of bystander epithelial cells. The consequence is gene modifications which initiate cellular transformation. The process of tumourigenesis is exacerbated by the sustained generation of pro-proliferative ROS, as well as by the release of neutrophil-derived cytokines and proteases, all of which contribute to tumour promotion and progression. It is now well recognised that, in addition to inflammation causing cancer, many cancers per se induce an inflammatory response, with a high magnitude of neutrophil influx being indicative of a poor prognosis. In this setting, CXC chemokines produced by tumours not only promote neutrophil influx and hyperreactivity, but also cause autocrine activation of the proliferation of the chemokine-producing tumour cells. These various mechanisms of inflammation-mediated tumourigenesis are the primary focus of this review, together with a consideration of neutrophil-targeted anti-inflammatory strategies with potential as adjunctive cancer therapy. en_US
dc.description.librarian am2014 en_US
dc.description.uri en_US
dc.identifier.citation Anderson R, Tintinger GR, Feldman C. Inflammation and cancer: The role of the human neutrophil. S Afr J Sci. 2014;110(1/2), Art. #2013-0207, 6 pages. 10.1590/sajs.2014/20130207 en_US
dc.identifier.issn 0038-2353 (print)
dc.identifier.issn 1996-7489 (online)
dc.identifier.other 10.1590/sajs.2014/20130207
dc.language.iso en en_US
dc.publisher AOSIS Open Journals en_US
dc.rights © 2014. The Authors. Published under a Creative Commons Attribution Licence. en_US
dc.subject Angiogenesis en_US
dc.subject Chemokines en_US
dc.subject Cytokines en_US
dc.subject Hydrogen peroxide en_US
dc.subject Proteinases en_US
dc.subject Redox signalling en_US
dc.subject Reactive oxygen species en_US
dc.title Inflammation and cancer : the role of the human neutrophil en_US
dc.type Article en_US

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