Inflammation and cancer : the role of the human neutrophil

dc.contributor.authorAnderson, Ronald
dc.contributor.authorTintinger, Gregory Ronald
dc.contributor.authorFeldman, Charles
dc.contributor.emailronald.anderson@up.ac.zaen_US
dc.date.accessioned2014-06-06T09:29:34Z
dc.date.available2014-06-06T09:29:34Z
dc.date.issued2014-01
dc.description.abstractChronic inflammation of both infective and non-infective origin has been implicated in the aetiology of approximately 30% of all human epithelial malignancies. The primary carcinogens are reactive oxygen species (ROS) derived from activated, infiltrating cells of the innate immune system, especially neutrophils, which inflict oxidative damage on the DNA of bystander epithelial cells. The consequence is gene modifications which initiate cellular transformation. The process of tumourigenesis is exacerbated by the sustained generation of pro-proliferative ROS, as well as by the release of neutrophil-derived cytokines and proteases, all of which contribute to tumour promotion and progression. It is now well recognised that, in addition to inflammation causing cancer, many cancers per se induce an inflammatory response, with a high magnitude of neutrophil influx being indicative of a poor prognosis. In this setting, CXC chemokines produced by tumours not only promote neutrophil influx and hyperreactivity, but also cause autocrine activation of the proliferation of the chemokine-producing tumour cells. These various mechanisms of inflammation-mediated tumourigenesis are the primary focus of this review, together with a consideration of neutrophil-targeted anti-inflammatory strategies with potential as adjunctive cancer therapy.en_US
dc.description.librarianam2014en_US
dc.description.urihttp://www.sajs.co.za/en_US
dc.identifier.citationAnderson R, Tintinger GR, Feldman C. Inflammation and cancer: The role of the human neutrophil. S Afr J Sci. 2014;110(1/2), Art. #2013-0207, 6 pages. http://dx.DOI.org/ 10.1590/sajs.2014/20130207en_US
dc.identifier.issn0038-2353 (print)
dc.identifier.issn1996-7489 (online)
dc.identifier.other10.1590/sajs.2014/20130207
dc.identifier.urihttp://hdl.handle.net/2263/40045
dc.language.isoenen_US
dc.publisherAOSIS Open Journalsen_US
dc.rights© 2014. The Authors. Published under a Creative Commons Attribution Licence.en_US
dc.subjectAngiogenesisen_US
dc.subjectChemokinesen_US
dc.subjectCytokinesen_US
dc.subjectHydrogen peroxideen_US
dc.subjectProteinasesen_US
dc.subjectRedox signallingen_US
dc.subjectReactive oxygen speciesen_US
dc.titleInflammation and cancer : the role of the human neutrophilen_US
dc.typeArticleen_US

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