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Browsing Natural and Agricultural Sciences by UP Author "Pilcher, Lynne A."
Now showing items 1-19 of 19
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Khazir, Jabeena; Mir, Bilal Ahmad; Pilcher, Lynne A.; Riley, Darren L.; Cowan, Don A. (Natural Product, 2014-11)Cancer is one of the major causes of death and the number of new cases, as well as the number of individuals living with cancer, is expanding continuously. Worldwide the alarming rise in mortality rate due to cancer has ...
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Driver, Kathy (Cathryn Helena Stanford); Balogun, Mohammed Olusegun; Toschi, Gianna; Verschoor, J.A. (Jan Adrianus), 1953-; Baird, Mark S.; Pilcher, Lynne A. (Elsevier, 2010-02)A new method for the stereoselective synthesis of the (R,R)-b-hydroxy-a-alkyl fatty acid fragment of mycolic acids, via an asymmetric anti-aldol reaction is reported. The ‘mycolic acid motif’ fragment was prepared in three ...
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Tekane, Rethabile; Pilcher, Lynne A.; Potgieter, Marietjie (Royal Society of Chemistry, 2020)Although the implementation of blended learning in organic chemistry is rapidly growing, thus far, there are few studies published on the evaluation of supplemental types of blend in organic chemistry. This report covers ...
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Pilcher, Lynne A.; Potgieter, Marietjie; Fletcher, Lizelle (Routledge, 2023)The logistics and cost of running large class tutorials to improve learning for students in high enrolment courses raise questions about whether the associated effort and cost are worthwhile. The option to replace these ...
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Buyens, Dominique M.S.; Pilcher, Lynne A.; Cukrowski, Ignacy (MDPI, 2022-09-19)The adeninate anion (Ade) is a useful nucleophile used in the synthesis of many prodrugs (including those for HIV AIDS treatment). It exists as a contact ion-pair (CIP) with Na+ and K+ (M+) but the site of coordination is ...
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Khazir, Jabeena; Mir, Bilal Ahmad; Pilcher, Lynne A.; Riley, Darren L.; Chashoo, Gousia; Islam, Md Ataul; Saxena, Ajit K.; Kumar, H.M.S. (Halmuthur Mahabalarao Sampath) (Springer, 2016-09)Here we describe ring opening reaction of a novel halo triene derivative viz., (3S, 5aS)-8- chloro-3a, 4, 5, 5a-tetrahydro-3, 5a, 9-trimethylnaphtho [1, 2-b] furan-2(3H)-one of α- santonin upon nucleophillic attack with ...
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Kabwe, Kapambwe Peter; Nsibande, Sifiso Albert; Pilcher, Lynne A.; Forbes, Patricia B.C. (Wiley, 2022-11)The development of amine-functionalized graphene quantum dots (GQDs) linked to mycolic acids (MAs) as a potential fluorescent biosensor to detect tuberculosis (TB) biomarkers is described. GQDs have attractive properties: ...
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Pilcher, Lynne A. (De Gruyter, 2024-01)In response to the IUPAC call to introduce systems thinking in tertiary chemistry education, we have developed and implemented two interventions at the first-year undergraduate level: one was designed to integrate systems ...
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Pilcher, Lynne A.; Riley, Darren L.; Mathabathe, Kgadi Clarrie; Potgieter, Marietjie (South African Chemical Institute, 2015)This paper describes the development of a new practical curriculum for third-year organic chemistry to replace the recipe-based approach typically used in undergraduate teaching laboratories. The new curriculum consists ...
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Buyens, Dominique M.S.; Pilcher, Lynne A. (Wiley, 2023-10)The alkylation of adenine using alkyl halides under basic conditions in dimethyl sulfoxide (DMSO), a common reaction to achieve N9-alkylated adenine derivatives, is often low yielding with unreacted adenine and ...
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Mvango, Sindisiwe; Matshe, William M.R.; Balogun, Abideen O.; Pilcher, Lynne A.; Balogun, Mohammed O. (Springer, 2018-12)Malaria is one of the oldest infectious diseases that afflict humans and its history extends back for millennia. It was once prevalent throughout the globe but today it is mainly endemic to tropical regions like sub-Saharan ...
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Mvango, Sindisiwe; Mthimkhulu, Nompumelelo; Fru, Pascaline Nanga; Pilcher, Lynne A.; Balogun, Mohammed O. (American Institute of Physics, 2020-11)Betulinic acid (BA) is a naturally occurring plant pentacyclic triterpenoid with activity against cancer and infectious diseases like malaria and AIDS. Its pharmacological activity is limited by low aqueous solubility and ...
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Khazir, Jabeena; Mir, Bilal Ahmad; Pilcher, Lynne A.; Riley, Darren L. (Elsevier, 2014-02)Cancer is one of the major causes of death and the number of new cases, as well as the number of individuals living with cancer, is expanding continuously. Worldwide the alarming rise in mortality rate due to cancer has ...
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Buyens, Dominique M.S.; Mangondo, Paidamwoyo; Cukrowski, Ignacy; Pilcher, Lynne A. (Wiley, 2017-09)Please read abstract in the article.
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Sharma, Kamlesh; Laurens, Johannes B.; Pilcher, Lynne A. (Routledge, 2009)On exposure to the potential carcinogen 1,3-butadiene, the major urinary metabolite in humans is N-acetyl-S-(3,4-dihydroxybutyl)cysteine. A novel, stereoselective synthesis of this cysteine–butadiene metabolite has ...
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Tshweu, Lesego L.; Shemis, Mohamed A.; Abdelghany, Aya; Gouda, Abdullah; Pilcher, Lynne A.; Sibuyi, Nicole R.S.; Meyer, Mervin; Dube, Admire; Balogun, Mohammed O. (Royal Society of Chemistry, 2020-06)Antibiotic resistance is increasing at such an alarming rate that it is now one of the greatest global health challenges. Undesirable toxic side-effects of the drugs lead to high rates of non-completion of treatment ...
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Reynders, Micke; Pilcher, Lynne A.; Potgieter, Marietjie (American Chemical Society, 2023-03)Powerful arguments have been made recently to advocate for the introduction of systems thinking in chemistry education to equip graduates to address sustainability challenges. This contribution describes systems thinking ...
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Balogun, Mohammed Olusegun; Huws, Enlli; Sirhan, Muthana M.; Saleh, Ahmed D.; Al Dulayymi, Juma’a R.; Pilcher, Lynne A.; Verschoor, J.A. (Jan Adrianus), 1953-; Baird, Mark S. (Elsevier, 2013-07)Patient serum antibodies to mycolic acids have the potential to be surrogate markers of active tuberculosis (TB) when they can be distinguished from the ubiquitously present cross-reactive antibodies to cholesterol. ...
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Buyens, Dominique M.S.; Pilcher, Lynne A.; Roduner, Emil (Wiley, 2021-10)Rare anionic forms of nucleic acids play a significant biological role and lead to spontaneous mutations and replication and translational errors. There is a lack of information surrounding the stability and reactivity of ...
Now showing items 1-19 of 19