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A biomimetic approach to the synthesis of a mycolic acid motif
Driver, Kathy (Cathryn Helena Stanford); Balogun, Mohammed Olusegun; Toschi, Gianna; Verschoor, J.A. (Jan Adrianus), 1953-; Baird, Mark S.; Pilcher, Lynne A.
A new method for the stereoselective synthesis of the (R,R)-b-hydroxy-a-alkyl fatty acid fragment of
mycolic acids, via an asymmetric anti-aldol reaction is reported. The ‘mycolic acid motif’ fragment was prepared in three steps and >98% ee.
