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Browsing Natural and Agricultural Sciences by Author "Millar, Robert P."
Now showing items 21-40 of 47
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Mayevua, Nkateko M.I.; Choe, Han; Abagyan, Ruben; Seong, Jae Young; Millar, Robert P.; Katz, Arieh A.; Flanagan, Colleen A. (Elsevier, 2015-02)Please read abstract in the article.
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Sonigo, Charlotte; Bouilly, Justine; Carre, Nadège; Tolle, Virginie; Caraty, Alain; Tello, Javier A.; Simony-Conesa, Fabian-Jesus; Millar, Robert P.; Young, Jacques; Binart, Nadine (American Society for Clinical Investigation, 2012-10)Hyperprolactinemia is the most common cause of hypogonadotropic anovulation and is one of the leading causes of infertility in women aged 25–34. Hyperprolactinemia has been proposed to block ovulation through inhibition ...
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Millar, Robert P. (2014-09)The dogmatic adherence to “what is good for the goose is good for the gander” appears to pervade avian endocrinology research when it comes to vertebrate evolution of hormones and their physiological roles in birds. There ...
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Topaloglu, A. Kemal; Tello, Javier A.; Kotan, L. Damla; Ozbek, Mehmet N.; Yilmaz, M. Bertan; Erdogan, Seref; Gurbuz, Fatih; Temiz, Fatih; Millar, Robert P.; Yuksel, Bilgin (Massachusetts Medical Society, 2012-02-16)Gonadotropin-releasing hormone (GnRH) is the central regulator of gonadotropins, which stimulate gonadal function. Hypothalamic neurons that produce kisspeptin and neurokinin B stimulate GnRH release. Inactivating mutations ...
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Skorupskaite, Karolina; George, Jyothis T.; Veldhuis, Johannes D.; Millar, Robert P.; Anderson, Richard A. (The Endocrine Society, 2016-12)CONTEXT : Kisspeptin and neurokinin B (NKB) are obligate for normal gonadotropin secretion, but their hierarchy is unexplored in normal women. Objective: To investigate the interaction between kisspeptin and NKB on ...
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Millar, Robert P.; Babwah, Andy V. (Karger, 2015-06)Kisspeptin (KP) is now well recognized as a potent stimulator of gonadotropin-releasing hormone (GnRH) secretion and thereby a major regulator of the neuroendocrine-reproductive axis. KP signals via KISS1R, a G protein-coupled ...
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Zmora, Nilli; Stubblefield, John David; Wong, Ten-Tsao; Levavi-Sivan, Berta; Millar, Robert P.; Zohar, Yonathan (Society for the Study of Reproduction, 2015-09)The importance of kisspeptin in regulating vertebrate reproduction has been well established, but the exact mechanism continues to unfold. Unlike mammals, many lower vertebrates possess a dual kisspeptin system, Kiss1 ...
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Francis, Victor A.; Abera, Aron B.; Matjila, Mushi; Millar, Robert P.; Katz, Arieh A.; Ulasov, Ilya (Public Library of Science, 2014-06-12)The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell metastasis and placental trophoblast cell ...
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De Bond, Julie-Ann P.; Li, Qun; Millar, Robert P.; Clarke, Iain J.; Smith, Jeremy T.; Vaudry, Hubert (Public Library of Science, 2013-02-28)The introduction of a novel male stimulates the hypothalamic-pituitary-gonadal axis of female sheep during seasonal anestrus, leading to the resumption of follicle maturation and ovulation. How this pheromone cue activates ...
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Goodman, Robert L.; Hileman, Stanley M.; Nestor, Casey C.; Porter, Katrina L.; Connors, John M.; Hardy, Steve L.; Millar, Robert P.; Cernea, Maria; Coolen, Lique M.; Lehman, Michael N. (The Endocrine Society, 2013-11)Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin driving GnRH release and neurokinin B (NKB) and ...
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George, J.T.; Veldhuis, J.D.; Roseweir, A.K.; Newton, Claire L.; Faccenda, E.; Millar, Robert P.; Anderson, Richard A. (The Endocrine Society, 2011-08)CONTEXT: Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been studied in man. OBJECTIVE: We investigated our ...
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Moon, Mi Jin; Lee, Yoo-Na; Park, Sumi; Reyes-Alcaraz, Arfaxad; Hwang, Jong-Ik; Millar, Robert P.; Choe, Han; Seong, Jae Young (American Society for Biochemistry and Molecular Biology, 2015-02)BACKGROUND : Little is known about the interaction between GLP-1 and the heptahelical core domain of GLP1R. RESULTS : GLP-1 Asp9 and Gly4 interact with the evolutionarily conserved residues in extracellular loop ...
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Newton, Claire L.; Anderson, Ross Calley; Katz, Arieh Anthony; Millar, Robert P. (Endocrinology Society, 2016-11)
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Viljoen, Ignatius M.; Van Helden, Paul David; Millar, Robert P. (Elsevier, 2015-06)Mycobacterium bovis has global public-health and socio-economic significance and can infect a wide range of species including the lion (Panthera leo) resulting in tuberculosis. Lions are classified as vulnerable under ...
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Skorupskaite, Karolina; George, Jyothis T.; Veldhuis, Johannes D.; Millar, Robert P.; Anderson, Richard A. (John Wiley & Sons Ltd., 2017-12)OBJECTIVE : Patients with mutations of neurokinin B (NKB) and its receptor show hypogonadotrophic hypogonadism, but there is little evidence for the importance of this pathway in reproductive function in normal men, or ...
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Skorupskaite, Karolina; George, Jyothis T.; Veldhuis, Johannes D.; Millar, Robert P.; Anderson, Richard A. (Karger, 2018-04-05)OBJECTIVES : Neurokinin B (NKB) and kisspeptin are obligate for normal gonadotropin secretion, and links between gonadotropin- releasing hormone (GnRH) pulsatility and vasomotor symptoms have been proposed. Using a ...
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Grachev, Pasha; Li, X.F.; Hu, M.H.; Li, S.Y.; Millar, Robert P.; Lightman, Stafford L.; O'Byrne, Kevin T. (The Endocrine Society, 2014-04-07)Acute systemic stress disrupts reproductive function by inhibiting pulsatile gonadotropin secretion. The underlying mechanism involves stress-induced suppression of the GnRH pulse generator, the functional unit of which ...
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Park, Cho Rong; Moon, Mi Jin; Park, Sumi; Kim, Dong-Kyu; Cho, Eun Bee; Millar, Robert P.; Hwang, Jong-Ik; Seong, Jae Young (Public Library of Science, 2013-06-11)The glucagon (GCG) peptide family consists of GCG, glucagon-like peptide 1 (GLP1), and GLP2, which are derived from a common GCG precursor, and the glucose-dependent insulinotropic polypeptide (GIP). These peptides interact ...
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Van der Goot, A.C. (Annemieke Catharina); Martin, G.B.; Millar, Robert P.; Paris, Monique C.J.; Ganswindt, Andre (Elsevier, 2015-10)Unlike their wild counterparts, many white rhinoceros females in captivity fail to reproduce successfully such that current captive populations are not self-sustaining. The causes of the problem are poorly understood. ...
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Munro, Kirsty I.; Thrippleton, Michael J.; Williams, Alistair R.W.; McKillop, Graham; Walker, Jane B.; Horne, Andrew W.; Newby, David E.; Anderson, Richard A.; Semple, Scott I.; Marshall, Ian; Lewis, Steff C.; Millar, Robert P.; Bastin, Mark E.; Critchley, Hilary O.D. (Public Library of Science, 2014-03-07)OBJECTIVE: There are no long-term medical treatments for uterine fibroids, and non-invasive biomarkers are needed to evaluate novel therapeutic interventions. The aim of this study was to determine whether serial dynamic ...
Now showing items 21-40 of 47