BACKGROUND : Little is known about the interaction between GLP-1 and the heptahelical core domain of GLP1R.
RESULTS : GLP-1 Asp9 and Gly4 interact with the evolutionarily conserved residues in extracellular loop 3.
CONCLUSION : Ligand binding pocket formed by evolutionarily conserved residues in the GLP1R core domain.
Significance: This study highlights the mechanism underlying high affinity interaction between GLP-1 and the binding pocket
of the receptor.