Vascular endothelial growth factor concentrations in dogs with Spirocercosis

Show simple item record Mukorera, Varaidzo Kirberger, Robert M. Mabeta, Peaceful Lucy Dvir, Eran 2014-02-03T09:14:29Z 2014-02-03T09:14:29Z 2013-11
dc.description.abstract BACKGROUND : Vascular endothelial growth factor (VEGF) is a potent proangiogenic factor associated with tumor development.Spirocerca lupi is a nematode of canids that induces an esophageal nodule that progresses to a sarcoma in 25% of cases. Determination of neoplastic transformation is challenging and usually based on endoscopy-guided biopsies under general anesthesia, an expensive procedure that often yields nondiagnostic, necrotic samples. HYPOTHESIS : Circulatory VEGF concentrations are increased in dogs with neoplastic spirocercosis and can distinguish between dogs with neoplastic and nonneoplastic disease. ANIMALS : A total of 24 client-owned dogs, 9 nonneoplastic, 9 neoplastic, and 6 controls. METHODS : Case-control study. Plasma and serum VEGF concentrations at the time of diagnosis were compared with those of healthy controls. Measurement of VEGF was performed using a canine-specific ELISA. Kruskal-Wallis and Dunn’s tests were used for statistical analysis with significance set at P < .05. RESULTS : The median plasma VEGF concentrations of dogs with neoplastic spirocercosis were 629 pg/mL (range, 282– 2,366) higher than both the nonneoplastic (<39.5 pg/mL; range, <39.5–716) and control dogs (<39.5 pg/mL; all values, <39.5; P = .0003). The median serum VEGF concentration of the neoplastic dogs was 69 pg/mL (range, <39.5–212) higher than the nonneoplastic (<39.5 pg/mL; range, <39.5–44.13) and control dogs (<39.5 pg/mL; all values, <39.5; P = .001). CONCLUSIONS AND CLINICAL IMPORTANCE : Both plasma and serum VEGF concentrations can be used to differentiate nonneoplastic and neoplastic spirocercosis. The role of VEGF in neoplastic transformation of S. lupi-induced nodules and the potential utility of anti-VEGF drugs in spirocercosis-induced sarcoma warrant further investigation. en
dc.description.librarian hb2014 en
dc.description.librarian mn2014
dc.description.sponsorship South African National Research Foundation and the Faculty of Veterinary Science, University of Pretoria, South Africa. en
dc.description.uri en
dc.identifier.citation Mukorera, V, Kirberger, RM, Mabeta, P & Dvir, E 2013, 'Vascular endothelial growth factor concentrations in dogs with Spirocercosis', Journal of Veterinary Internal Medicine, vol. 27, no. 6, pp. 1642-1645. en
dc.identifier.issn 0891-6640 (print)
dc.identifier.issn 1939-1676 (online)
dc.identifier.other 10.1111/jvim.12179
dc.identifier.other 7004586182
dc.identifier.other 7004445917
dc.identifier.other N-8699-2014
dc.identifier.other G-9725-2014
dc.identifier.other 12791859400
dc.language.iso en en
dc.publisher Wiley-Blackwell en
dc.rights © 2013 by the American College of Veterinary Internal Medicine en
dc.subject Canine esophagus en
dc.subject Neoplastic en
dc.subject Nonneoplastic en
dc.subject Vascular endothelial growth factor (VEGF) en
dc.subject.lcsh Dogs -- Diseases en
dc.title Vascular endothelial growth factor concentrations in dogs with Spirocercosis en
dc.type Postprint Article en

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