Vascular endothelial growth factor concentrations in dogs with Spirocercosis

dc.contributor.authorMukorera, Varaidzo
dc.contributor.authorKirberger, Robert M.
dc.contributor.authorMabeta, Peaceful Lucy
dc.contributor.authorDvir, Eran
dc.contributor.emailvaraidzo.mukorera@up.ac.zaen
dc.date.accessioned2014-02-03T09:14:29Z
dc.date.available2014-02-03T09:14:29Z
dc.date.issued2013-11
dc.description.abstractBACKGROUND : Vascular endothelial growth factor (VEGF) is a potent proangiogenic factor associated with tumor development.Spirocerca lupi is a nematode of canids that induces an esophageal nodule that progresses to a sarcoma in 25% of cases. Determination of neoplastic transformation is challenging and usually based on endoscopy-guided biopsies under general anesthesia, an expensive procedure that often yields nondiagnostic, necrotic samples. HYPOTHESIS : Circulatory VEGF concentrations are increased in dogs with neoplastic spirocercosis and can distinguish between dogs with neoplastic and nonneoplastic disease. ANIMALS : A total of 24 client-owned dogs, 9 nonneoplastic, 9 neoplastic, and 6 controls. METHODS : Case-control study. Plasma and serum VEGF concentrations at the time of diagnosis were compared with those of healthy controls. Measurement of VEGF was performed using a canine-specific ELISA. Kruskal-Wallis and Dunn’s tests were used for statistical analysis with significance set at P < .05. RESULTS : The median plasma VEGF concentrations of dogs with neoplastic spirocercosis were 629 pg/mL (range, 282– 2,366) higher than both the nonneoplastic (<39.5 pg/mL; range, <39.5–716) and control dogs (<39.5 pg/mL; all values, <39.5; P = .0003). The median serum VEGF concentration of the neoplastic dogs was 69 pg/mL (range, <39.5–212) higher than the nonneoplastic (<39.5 pg/mL; range, <39.5–44.13) and control dogs (<39.5 pg/mL; all values, <39.5; P = .001). CONCLUSIONS AND CLINICAL IMPORTANCE : Both plasma and serum VEGF concentrations can be used to differentiate nonneoplastic and neoplastic spirocercosis. The role of VEGF in neoplastic transformation of S. lupi-induced nodules and the potential utility of anti-VEGF drugs in spirocercosis-induced sarcoma warrant further investigation.en
dc.description.librarianhb2014en
dc.description.librarianmn2014
dc.description.sponsorshipSouth African National Research Foundation and the Faculty of Veterinary Science, University of Pretoria, South Africa.en
dc.description.urihttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1939-1676en
dc.identifier.citationMukorera, V, Kirberger, RM, Mabeta, P & Dvir, E 2013, 'Vascular endothelial growth factor concentrations in dogs with Spirocercosis', Journal of Veterinary Internal Medicine, vol. 27, no. 6, pp. 1642-1645.en
dc.identifier.issn0891-6640 (print)
dc.identifier.issn1939-1676 (online)
dc.identifier.other10.1111/jvim.12179
dc.identifier.other7004586182
dc.identifier.other7004445917
dc.identifier.otherN-8699-2014
dc.identifier.otherG-9725-2014
dc.identifier.other12791859400
dc.identifier.urihttp://hdl.handle.net/2263/33205
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.rights© 2013 by the American College of Veterinary Internal Medicineen
dc.subjectCanine esophagusen
dc.subjectNeoplasticen
dc.subjectNonneoplasticen
dc.subjectVascular endothelial growth factor (VEGF)en
dc.subject.lcshDogs -- Diseasesen
dc.titleVascular endothelial growth factor concentrations in dogs with Spirocercosisen
dc.typePostprint Articleen

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