Vascular endothelial growth factor concentrations in dogs with Spirocercosis
dc.contributor.author | Mukorera, Varaidzo | |
dc.contributor.author | Kirberger, Robert M. | |
dc.contributor.author | Mabeta, Peaceful Lucy | |
dc.contributor.author | Dvir, Eran | |
dc.contributor.email | varaidzo.mukorera@up.ac.za | en |
dc.date.accessioned | 2014-02-03T09:14:29Z | |
dc.date.available | 2014-02-03T09:14:29Z | |
dc.date.issued | 2013-11 | |
dc.description.abstract | BACKGROUND : Vascular endothelial growth factor (VEGF) is a potent proangiogenic factor associated with tumor development.Spirocerca lupi is a nematode of canids that induces an esophageal nodule that progresses to a sarcoma in 25% of cases. Determination of neoplastic transformation is challenging and usually based on endoscopy-guided biopsies under general anesthesia, an expensive procedure that often yields nondiagnostic, necrotic samples. HYPOTHESIS : Circulatory VEGF concentrations are increased in dogs with neoplastic spirocercosis and can distinguish between dogs with neoplastic and nonneoplastic disease. ANIMALS : A total of 24 client-owned dogs, 9 nonneoplastic, 9 neoplastic, and 6 controls. METHODS : Case-control study. Plasma and serum VEGF concentrations at the time of diagnosis were compared with those of healthy controls. Measurement of VEGF was performed using a canine-specific ELISA. Kruskal-Wallis and Dunn’s tests were used for statistical analysis with significance set at P < .05. RESULTS : The median plasma VEGF concentrations of dogs with neoplastic spirocercosis were 629 pg/mL (range, 282– 2,366) higher than both the nonneoplastic (<39.5 pg/mL; range, <39.5–716) and control dogs (<39.5 pg/mL; all values, <39.5; P = .0003). The median serum VEGF concentration of the neoplastic dogs was 69 pg/mL (range, <39.5–212) higher than the nonneoplastic (<39.5 pg/mL; range, <39.5–44.13) and control dogs (<39.5 pg/mL; all values, <39.5; P = .001). CONCLUSIONS AND CLINICAL IMPORTANCE : Both plasma and serum VEGF concentrations can be used to differentiate nonneoplastic and neoplastic spirocercosis. The role of VEGF in neoplastic transformation of S. lupi-induced nodules and the potential utility of anti-VEGF drugs in spirocercosis-induced sarcoma warrant further investigation. | en |
dc.description.librarian | hb2014 | en |
dc.description.librarian | mn2014 | |
dc.description.sponsorship | South African National Research Foundation and the Faculty of Veterinary Science, University of Pretoria, South Africa. | en |
dc.description.uri | http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1939-1676 | en |
dc.identifier.citation | Mukorera, V, Kirberger, RM, Mabeta, P & Dvir, E 2013, 'Vascular endothelial growth factor concentrations in dogs with Spirocercosis', Journal of Veterinary Internal Medicine, vol. 27, no. 6, pp. 1642-1645. | en |
dc.identifier.issn | 0891-6640 (print) | |
dc.identifier.issn | 1939-1676 (online) | |
dc.identifier.other | 10.1111/jvim.12179 | |
dc.identifier.other | 7004586182 | |
dc.identifier.other | 7004445917 | |
dc.identifier.other | N-8699-2014 | |
dc.identifier.other | G-9725-2014 | |
dc.identifier.other | 12791859400 | |
dc.identifier.uri | http://hdl.handle.net/2263/33205 | |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.rights | © 2013 by the American College of Veterinary Internal Medicine | en |
dc.subject | Canine esophagus | en |
dc.subject | Neoplastic | en |
dc.subject | Nonneoplastic | en |
dc.subject | Vascular endothelial growth factor (VEGF) | en |
dc.subject.lcsh | Dogs -- Diseases | en |
dc.title | Vascular endothelial growth factor concentrations in dogs with Spirocercosis | en |
dc.type | Postprint Article | en |