Loss-of-function (LOF) (i.e., nonsense, splice site,
and frameshift) variants that lead to disruption of
gene function are likely to contribute to the etiology
of neuropsychiatric disorders. Here, we perform a
systematic ...
Ionita-Laza, Iuliana; Xu, Bin; Makarov, Vlad; Buxbaum, Joseph D.; Roos, J.L. (Johannes Louw); Gogos, Joseph A.; Karayiorgou, Maria(National Academy of Sciences, 2014-01)
We used a family-based cluster detection approach designed to
localize significant rare disease–risk variants clusters within a region
of interest to systematically search for schizophrenia (SCZ)
susceptibility genes ...
