Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites
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| dc.contributor.author | Niemand, Jandeli
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| dc.contributor.author | Burger, Pieter Buys
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| dc.contributor.author | Verlinden, Bianca K.
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| dc.contributor.author | Reader, Janette
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| dc.contributor.author | Joubert, Annie M.
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| dc.contributor.author | Kaiser, Annette
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| dc.contributor.author | Louw, Abraham Izak
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| dc.contributor.author | Kirk, Kiaran
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| dc.contributor.author | Phanstiel IV, Otto
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| dc.contributor.author | Birkholtz, Lyn-Marie
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| dc.date.accessioned | 2013-10-02T07:04:24Z | |
| dc.date.available | 2013-10-02T07:04:24Z | |
| dc.date.issued | 2013-06 | |
| dc.description.abstract | Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in the nM-μM range. The compounds are taken up into the intraerythrocytic parasite where they arrest the parasite cell-cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect. | en_US |
| dc.description.librarian | hb2013 | en_US |
| dc.description.sponsorship | JN was supported by the Carl and Emily Fuchs foundation, AusAID, the Ernst and Ethel Eriksen Trust, UP Mentorship Programme and the Claude Leon Foundation. This work was supported by the South African Medical Research Council, the South African National Research Foundation KISC programme (UID 67444), and the Australian National Health and Medical Research Council [Grant no. 525428 to KK]. | en_US |
| dc.description.uri | http://aac.asm.org | en_US |
| dc.identifier.citation | Niemand, J, Burger, P, Verlinden, BK, Reader, J, Joubert, AM, Kaiser, A, Louw, AI, Kirk, K, Phanstiel IV, O & Birkholtz, LM 2013, 'Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites', Antimicrobial Agents and Chemotherapy, vol. 57, no. 6, pp. 2874-2877. | en_US |
| dc.identifier.issn | 0066-4804 (print) | |
| dc.identifier.issn | 1098-6596 (online) | |
| dc.identifier.other | 10.1128/AAC.00106-13 | |
| dc.identifier.uri | http://hdl.handle.net/2263/31871 | |
| dc.language.iso | en | en_US |
| dc.publisher | American Society for Microbiology | en_US |
| dc.rights | © 2013, American Society for Microbiology. All Rights Reserved. | en_US |
| dc.subject | Malaria | en_US |
| dc.subject | Plasmodium falciparum | en_US |
| dc.subject | Spermidine | en_US |
| dc.subject | Putrescine | en_US |
| dc.subject | Anthracene | en_US |
| dc.title | Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites | en_US |
| dc.type | Postprint Article | en_US |
