Babesia lengau associated with cerebral and haemolytic babesiosis in two domestic cats

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dc.contributor.author Bosman, Anna-Mari
dc.contributor.author Oosthuizen, Marinda C.
dc.contributor.author Venter, Estelle Hildegard
dc.contributor.author Steyl, Johan Christian Abraham
dc.contributor.author Gous, Tertius A.
dc.contributor.author Penzhorn, Barend Louis
dc.date.accessioned 2013-09-23T07:25:06Z
dc.date.available 2013-09-23T07:25:06Z
dc.date.issued 2013-05-01
dc.description.abstract BACKGROUND: Although reported sporadically from various countries, feline babesiosis appears to be a significant clinical entity only in South Africa, where Babesia felis is usually incriminated as the causative agent. Babesia lengau, recently described from asymptomatic cheetahs, has now possibly been incriminated as the causative agent in two severe clinical cases in domestic cats. FINDINGS: Both cats were euthanised in extremis. While typical feline babesiosis in South Africa is an afebrile disease with a chronic manifestation, there was acute onset of severe clinical signs in both cats and their body temperatures were above the normal range when they were presented for treatment. Haemolytic anaemia was confirmed in one case. To our knowledge, this is the first report of cerebral babesiosis in cats. On reverse line blot 18S rDNA PCR products obtained from both cats showed positive hybridization profiles with the B. lengau species-specific probe. The two partial parasite 18S rRNA gene sequences obtained, showed high sequence similarity (99.9%) to B. lengau. In a representative tree constructed by the neighbor-joining method using the two-parameter model of Kimura the two obtained partial 18S rDNA sequences and that of B. lengau formed a monophyletic group with B. conradae and sequences previously isolated from humans and wildlife in the western USA. CONCLUSION: All clinical cases of feline babesiosis in South Africa are not necessarily caused by B. felis. Other piroplasms, e.g. B. lengau, may be incriminated in clinical cases, especially those occurring outside the known endemic area. en
dc.description.librarian am2013 en
dc.description.librarian mn2013
dc.description.sponsorship A South African National Research Foundation grant (NRF grant GUN 2069496) to BL Penzhorn. Publication of the CVBD8 thematic series has been sponsored by Bayer Animal Health GmbH. en
dc.description.uri http://www.parasitesandvectors.com/content/6/1/128 en
dc.identifier.citation Bosman et al.: Babesia lengau associated with cerebral and haemolytic babesiosis in two domestic cats. Parasites & Vectors 2013 6:128. en
dc.identifier.issn 1756-3305
dc.identifier.other 10.1186/1756-3305-6-128
dc.identifier.other 35609781000
dc.identifier.other 7003904650
dc.identifier.other 7004592997
dc.identifier.other J-7222-2013
dc.identifier.other N-8706-2014
dc.identifier.other O-6953-2014
dc.identifier.uri http://hdl.handle.net/2263/31784
dc.language.iso en en
dc.publisher BioMed Central en
dc.rights © 2013 Bosman et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License en
dc.subject Babesia lengau en
dc.subject Cerebral babesiosis en
dc.subject Feline babesiosis en
dc.subject Haemolytic anaemia en
dc.subject.lcsh Babesiosis in cats -- South Africa en
dc.subject.lcsh Cats -- Diseases en
dc.title Babesia lengau associated with cerebral and haemolytic babesiosis in two domestic cats en
dc.type Article en


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