Babesia lengau associated with cerebral and haemolytic babesiosis in two domestic cats

dc.contributor.authorBosman, Anna-Mari
dc.contributor.authorOosthuizen, Marinda C.
dc.contributor.authorVenter, Estelle Hildegard
dc.contributor.authorSteyl, Johan Christian Abraham
dc.contributor.authorGous, Tertius A.
dc.contributor.authorPenzhorn, Barend Louis
dc.contributor.emailbanie.penzhorn@up.ac.zaen
dc.date.accessioned2013-09-23T07:25:06Z
dc.date.available2013-09-23T07:25:06Z
dc.date.issued2013-05-01
dc.description.abstractBACKGROUND: Although reported sporadically from various countries, feline babesiosis appears to be a significant clinical entity only in South Africa, where Babesia felis is usually incriminated as the causative agent. Babesia lengau, recently described from asymptomatic cheetahs, has now possibly been incriminated as the causative agent in two severe clinical cases in domestic cats. FINDINGS: Both cats were euthanised in extremis. While typical feline babesiosis in South Africa is an afebrile disease with a chronic manifestation, there was acute onset of severe clinical signs in both cats and their body temperatures were above the normal range when they were presented for treatment. Haemolytic anaemia was confirmed in one case. To our knowledge, this is the first report of cerebral babesiosis in cats. On reverse line blot 18S rDNA PCR products obtained from both cats showed positive hybridization profiles with the B. lengau species-specific probe. The two partial parasite 18S rRNA gene sequences obtained, showed high sequence similarity (99.9%) to B. lengau. In a representative tree constructed by the neighbor-joining method using the two-parameter model of Kimura the two obtained partial 18S rDNA sequences and that of B. lengau formed a monophyletic group with B. conradae and sequences previously isolated from humans and wildlife in the western USA. CONCLUSION: All clinical cases of feline babesiosis in South Africa are not necessarily caused by B. felis. Other piroplasms, e.g. B. lengau, may be incriminated in clinical cases, especially those occurring outside the known endemic area.en
dc.description.librarianam2013en
dc.description.librarianmn2013
dc.description.sponsorshipA South African National Research Foundation grant (NRF grant GUN 2069496) to BL Penzhorn. Publication of the CVBD8 thematic series has been sponsored by Bayer Animal Health GmbH.en
dc.description.urihttp://www.parasitesandvectors.com/content/6/1/128en
dc.identifier.citationBosman et al.: Babesia lengau associated with cerebral and haemolytic babesiosis in two domestic cats. Parasites & Vectors 2013 6:128.en
dc.identifier.issn1756-3305
dc.identifier.other10.1186/1756-3305-6-128
dc.identifier.other35609781000
dc.identifier.other7003904650
dc.identifier.other7004592997
dc.identifier.otherJ-7222-2013
dc.identifier.otherN-8706-2014
dc.identifier.otherO-6953-2014
dc.identifier.urihttp://hdl.handle.net/2263/31784
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rights© 2013 Bosman et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen
dc.subjectBabesia lengauen
dc.subjectCerebral babesiosisen
dc.subjectFeline babesiosisen
dc.subjectHaemolytic anaemiaen
dc.subject.lcshBabesiosis in cats -- South Africaen
dc.subject.lcshCats -- Diseasesen
dc.titleBabesia lengau associated with cerebral and haemolytic babesiosis in two domestic catsen
dc.typeArticleen

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