In vitro effect of medicinal plants used to treat erectile dysfunction on smooth muscle relaxation and human sperm

Rakuambo, Ntungufhadzeni Christopher; Meyer, Jacobus Johannes Marion; Hussein, Ahmed A.; Huyser, Carin; Mdlalose, S.P.; Raidani, T.G.

dc.contributor.author	Rakuambo, Ntungufhadzeni Christopher
dc.contributor.author	Meyer, Jacobus Johannes Marion
dc.contributor.author	Hussein, Ahmed A.
dc.contributor.author	Huyser, Carin
dc.contributor.author	Mdlalose, S.P.
dc.contributor.author	Raidani, T.G.
dc.date.accessioned	2007-05-14T09:47:53Z
dc.date.available	2007-05-14T09:47:53Z
dc.date.issued	2006
dc.description.abstract	Chloroform and ethanol extracts of root bark of Securidaca longepedunculata, Wrightia natalensis and Rhoicissus tridentata were investigated for their in vitro activity on the contraction of corpus cavernosal smooth muscle of white New Zealand rabbits. Some of the extracts of these plants relaxed the corpus cavernosal smooth muscle at low concentrations. The highest activity was obtained from Securidaca longepedunculata chloroform extracts at a concentration of 13.0 mg/ml, which induced 66.6% relaxation. Viagra was used as a positive control in this study. Extracts of Securidaca longepedunculata added to human spermatozoa affected certain sperm parameters negatively at 6.5 mg/ml and higher whilst there was no effect at 1.0 mg/ml.	en
dc.description.sponsorship	The authors wish to thank Mr. Dick Carr for the free supply of the rabbit corpus cavenosum smooth muscle tissue and Mr. Billy Cloete (Faculty of Engineering, University of Pretoria) for assistance with the smooth muscle bioassay. We are grateful to traditional healers for their support during the development of the project. The study was supported in part by the National Research Foundation	en
dc.format.extent	118856 bytes
dc.format.mimetype	application/pdf
dc.identifier.citation	Rakuambo, NC, Meyer, JJM, Hussein, A, Huyser, C, Mdlalose, SP & Raidani, TG 2006. ‘In vitro effect of medicinal plants used to treat erectile dysfunction on smooth muscle relaxation and human sperm’, Journal of Ethnopharmacology, vol.105, issues 1-2, pp.84-88 [http://www.sciencedirect.com/science/journal/03788741]	en
dc.identifier.issn	0378-8741
dc.identifier.other	10.1016/j.jep.2005.10.008
dc.identifier.uri	http://hdl.handle.net/2263/2385
dc.language.iso	en	en
dc.publisher	Elsevier	en
dc.rights	Elsevier	en
dc.subject	Erectile dysfunction	en
dc.subject	Sperm parameters	en
dc.subject	Securidaca longepedunculata	en
dc.subject	Wrightia natalensis	en
dc.subject	Rhoicissus tridentata	en
dc.subject.lcsh	Medicinal plants	en
dc.subject.lcsh	Impotence -- Treatment	en
dc.subject.lcsh	Traditional medicine	en
dc.title	In vitro effect of medicinal plants used to treat erectile dysfunction on smooth muscle relaxation and human sperm	en
dc.type	Postprint Article	en