In vitro effect of medicinal plants used to treat erectile dysfunction on smooth muscle relaxation and human sperm
| dc.contributor.author | Rakuambo, Ntungufhadzeni Christopher | |
| dc.contributor.author | Meyer, Jacobus Johannes Marion | |
| dc.contributor.author | Hussein, Ahmed A. | |
| dc.contributor.author | Huyser, Carin | |
| dc.contributor.author | Mdlalose, S.P. | |
| dc.contributor.author | Raidani, T.G. | |
| dc.contributor.email | marion.meyer@up.ac.za | en |
| dc.date.accessioned | 2007-05-14T09:47:53Z | |
| dc.date.available | 2007-05-14T09:47:53Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | Chloroform and ethanol extracts of root bark of Securidaca longepedunculata, Wrightia natalensis and Rhoicissus tridentata were investigated for their in vitro activity on the contraction of corpus cavernosal smooth muscle of white New Zealand rabbits. Some of the extracts of these plants relaxed the corpus cavernosal smooth muscle at low concentrations. The highest activity was obtained from Securidaca longepedunculata chloroform extracts at a concentration of 13.0 mg/ml, which induced 66.6% relaxation. Viagra was used as a positive control in this study. Extracts of Securidaca longepedunculata added to human spermatozoa affected certain sperm parameters negatively at 6.5 mg/ml and higher whilst there was no effect at 1.0 mg/ml. | en |
| dc.description.sponsorship | The authors wish to thank Mr. Dick Carr for the free supply of the rabbit corpus cavenosum smooth muscle tissue and Mr. Billy Cloete (Faculty of Engineering, University of Pretoria) for assistance with the smooth muscle bioassay. We are grateful to traditional healers for their support during the development of the project. The study was supported in part by the National Research Foundation | en |
| dc.format.extent | 118856 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.citation | Rakuambo, NC, Meyer, JJM, Hussein, A, Huyser, C, Mdlalose, SP & Raidani, TG 2006. ‘In vitro effect of medicinal plants used to treat erectile dysfunction on smooth muscle relaxation and human sperm’, Journal of Ethnopharmacology, vol.105, issues 1-2, pp.84-88 [http://www.sciencedirect.com/science/journal/03788741] | en |
| dc.identifier.issn | 0378-8741 | |
| dc.identifier.other | 10.1016/j.jep.2005.10.008 | |
| dc.identifier.uri | http://hdl.handle.net/2263/2385 | |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | en |
| dc.rights | Elsevier | en |
| dc.subject | Erectile dysfunction | en |
| dc.subject | Sperm parameters | en |
| dc.subject | Securidaca longepedunculata | en |
| dc.subject | Wrightia natalensis | en |
| dc.subject | Rhoicissus tridentata | en |
| dc.subject.lcsh | Medicinal plants | en |
| dc.subject.lcsh | Impotence -- Treatment | en |
| dc.subject.lcsh | Traditional medicine | en |
| dc.title | In vitro effect of medicinal plants used to treat erectile dysfunction on smooth muscle relaxation and human sperm | en |
| dc.type | Postprint Article | en |