Screening of the venoms of two Parabuthus scorpion species on isolated cardiomyocytes
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Date
Authors
Van Aarde, M.N.
Van Rooyen, J.M.
Van Aswegen, G.
Journal Title
Journal ISSN
Volume Title
Publisher
Published by the Agricultural Research Council, Onderstepoort Veterinary Institute
Abstract
Crude, diluted venoms of Parabuthus transvaalicus and P. granulatus were tested on isolated
cardiomyocytes. Ventricular myocytes were subjected to hypercontractility tests and whole-cell voltage
clamp. Both venoms had a profound influence on the hypercontractility of cardiomyocytes, which
was markedly decreased when they were pre-absorbed with commercial antiserum. Whole-cell clamp
results showed an increase in the sodium current, and a retardation of the time course of inactivation,
implicating the presence of an a toxin in both venoms.
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Keywords
Veterinary medicine, Cardiomyocytes, Parabuthus granulatus, Parabuthus transvaalicus, Scorpions, Venom
Sustainable Development Goals
Citation
Van Aarde, MN, Van Rooyen, JM & Van Aswegen, G 1996, 'Screening of the venoms of two Parabuthus scorpion species on isolated cardiomyocytes’. Onderstepoort Journal of Veterinary Research, vol. 63, no. 2, pp. 127-130.