High within-host genetic variation of the nematode Spirocerca lupi in a high-density urban dog population

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dc.contributor.author De Waal, P.J. (Pamela Jean)
dc.contributor.author Gous, Annemarie
dc.contributor.author Clift, Sarah J.
dc.contributor.author Greeff, Jaco M. (Jacobus Maree)
dc.date.accessioned 2013-07-15T07:17:54Z
dc.date.available 2013-07-15T07:17:54Z
dc.date.issued 2012-06
dc.description.abstract The nematode worm Spirocerca lupi has a cosmopolitan distribution and can cause the death of its final canid host, typically dogs. While its life cycle, which involves a coprophagous beetle intermediate host, a number of non-obligatory vertebrate paratenic hosts and a canid final host, is well understood, surprisingly little is known about its transmission dynamics and population genetic structure. Here we sequenced cox1 to quantify genetic variation and the factors that limit gene flow in a 300 km2 area in South Africa. Three quarters of the genetic variation, was explained by differences between worms from the same host, whereas a quarter of the variation was explained by differences between worms from different hosts. With the help of a newly derived model we conclude that while the offspring from different infrapopulations mixes fairly frequently in new hosts, the level of admixture is not enough to homogenize the parasite populations among dogs. Small infrapopulation sizes along with clumped transmission may also result in members of infrapopulations being closely related. en_US
dc.description.librarian hb2013 en_US
dc.description.sponsorship AG was funded by the National Research Foundation (NRF) of South Africa grant GUN 2072974 to JMG.Running costs were covered by JMG and a Research Development grant from the University of Pretoria to PdW. en_US
dc.description.uri www.elsevier.com/locate/vetpar en_US
dc.identifier.citation De Waal, PJ, Gous, A , Clift, SJ & Greeff, JM 2012, 'High within-host genetic variation of the nematode Spirocerca lupi in a high-density urban dog population', Veterinay Parasitology, vol. 187, no.1/2, pp.259-266. en_US
dc.identifier.issn 0304-4017 (print)
dc.identifier.issn 1873-2550 (online)
dc.identifier.other 10.1016/j.vetpar.2011.12.008
dc.identifier.uri http://hdl.handle.net/2263/21945
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2011 Elsevier B.V. All rights reserved.Notice : this is the author’s version of a work that was accepted for publication in Veterinary Parasitology.Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Veterinary Parasitology, vol.187, no. 1/2, 2012, doi. : 10.1016/j.vetpar.2011.12.008 en_US
dc.subject Parasite en_US
dc.subject Canid en_US
dc.subject Population genetic structure en_US
dc.subject Nematode en_US
dc.subject Transmission en_US
dc.title High within-host genetic variation of the nematode Spirocerca lupi in a high-density urban dog population en_US
dc.type Postprint Article en_US


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