High within-host genetic variation of the nematode Spirocerca lupi in a high-density urban dog population

dc.contributor.authorDe Waal, Pamela Jean
dc.contributor.authorGous, Annemarie
dc.contributor.authorClift, Sarah Jane
dc.contributor.authorGreeff, Jacobus Maree
dc.contributor.emailjaco.greeff@up.ac.zaen_US
dc.date.accessioned2013-07-15T07:17:54Z
dc.date.available2013-07-15T07:17:54Z
dc.date.issued2012-06
dc.description.abstractThe nematode worm Spirocerca lupi has a cosmopolitan distribution and can cause the death of its final canid host, typically dogs. While its life cycle, which involves a coprophagous beetle intermediate host, a number of non-obligatory vertebrate paratenic hosts and a canid final host, is well understood, surprisingly little is known about its transmission dynamics and population genetic structure. Here we sequenced cox1 to quantify genetic variation and the factors that limit gene flow in a 300 km2 area in South Africa. Three quarters of the genetic variation, was explained by differences between worms from the same host, whereas a quarter of the variation was explained by differences between worms from different hosts. With the help of a newly derived model we conclude that while the offspring from different infrapopulations mixes fairly frequently in new hosts, the level of admixture is not enough to homogenize the parasite populations among dogs. Small infrapopulation sizes along with clumped transmission may also result in members of infrapopulations being closely related.en_US
dc.description.librarianhb2013en_US
dc.description.sponsorshipAG was funded by the National Research Foundation (NRF) of South Africa grant GUN 2072974 to JMG.Running costs were covered by JMG and a Research Development grant from the University of Pretoria to PdW.en_US
dc.description.uriwww.elsevier.com/locate/vetparen_US
dc.identifier.citationDe Waal, PJ, Gous, A , Clift, SJ & Greeff, JM 2012, 'High within-host genetic variation of the nematode Spirocerca lupi in a high-density urban dog population', Veterinay Parasitology, vol. 187, no.1/2, pp.259-266.en_US
dc.identifier.issn0304-4017 (print)
dc.identifier.issn1873-2550 (online)
dc.identifier.other10.1016/j.vetpar.2011.12.008
dc.identifier.urihttp://hdl.handle.net/2263/21945
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2011 Elsevier B.V. All rights reserved.Notice : this is the author’s version of a work that was accepted for publication in Veterinary Parasitology.Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Veterinary Parasitology, vol.187, no. 1/2, 2012, doi. : 10.1016/j.vetpar.2011.12.008en_US
dc.subjectParasiteen_US
dc.subjectCaniden_US
dc.subjectPopulation genetic structureen_US
dc.subjectNematodeen_US
dc.subjectTransmissionen_US
dc.titleHigh within-host genetic variation of the nematode Spirocerca lupi in a high-density urban dog populationen_US
dc.typePostprint Articleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
DeWaal_High(2012).pdf
Size:
2.08 MB
Format:
Adobe Portable Document Format
Description:
Postprint Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: