NT-ProBNP and cardiac troponin I in virulent canine babesiosis
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Date
Authors
Lobetti, R.G. (Remo Giuseppe)
Kirberger, Robert M.
Keller, Ninette
Kettner, Frank
Dvir, Eran
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Although cardiac pathology and consequently elevated serum cardiac troponin I (cTnI) have
been reported, clinically it remains difficult to diagnose cardiac involvement in canine
babesiosis. Thus the use of cardiac biomarkers would be useful in determining if a dog
with babesiosis also has concurrent cardiac dysfunction. The objectives of this study were
to determine plasma N terminal brain natriuretic peptide (NT-proBNP) in canine babesiosis
and if it is correlated with cTnI. Three groups of dogs with babesiosis were used: mild
uncomplicated (Group 1), severe uncomplicated (Group 2), and complicated (Group 3), and
a control group (Group 4) with 15 dogs per group. Each animal had the following determined:
serum urea and creatinine, urea: creatinine ratio, cystatin-C, cTnI, blood lactate,
plasma NT-proBNP, fractional shortening (FS), and blood pressure. The median NT-proBNP
value in Groups 1–4 was 246, 650, 638, and 106 pmol/l. All 3 babesiosis groups had a statistically
elevated NT-proBNP level compared to the control group and Groups 2 and 3 showed
significantly higher values compared to Group 1. Median cTnI in Group 1–3 was 0.39, 0.4,
and 1.45 ng/ml, respectively with the control group having concentrations below the detection
limit (0.2 ng/ml). There was a significant difference in cTnI concentration between the
control group and group 3 but no statistical difference between the other babesiosis groups.
The study concluded that dogs with babesiosis showed elevated levels NT-proBNP and
the more severe the disease process the greater the elevation. This elevation is earlier or
independent of the increased cTnI.
Description
Keywords
Cardiac biomarkers, BNP, Troponin, Dogs
Sustainable Development Goals
Citation
Remo Lobetti, Robert Kirberger, Ninette Keller, Frank Kettner & Eran Dvir, NT-ProBNP and cardiac troponin I in virulent canine babesiosis, Veterinary Parasitology, vol. 190, no. 3-4, pp. 333-339, (2012) doi: 10.1016/j.vetpar.2012.07.021