NT-ProBNP and cardiac troponin I in virulent canine babesiosis

dc.contributor.authorLobetti, R.G. (Remo Giuseppe)
dc.contributor.authorKirberger, Robert M.
dc.contributor.authorKeller, Ninette
dc.contributor.authorKettner, Frank
dc.contributor.authorDvir, Eran
dc.date.accessioned2012-12-12T06:55:43Z
dc.date.available2012-12-12T06:55:43Z
dc.date.issued2012-12-21
dc.description.abstractAlthough cardiac pathology and consequently elevated serum cardiac troponin I (cTnI) have been reported, clinically it remains difficult to diagnose cardiac involvement in canine babesiosis. Thus the use of cardiac biomarkers would be useful in determining if a dog with babesiosis also has concurrent cardiac dysfunction. The objectives of this study were to determine plasma N terminal brain natriuretic peptide (NT-proBNP) in canine babesiosis and if it is correlated with cTnI. Three groups of dogs with babesiosis were used: mild uncomplicated (Group 1), severe uncomplicated (Group 2), and complicated (Group 3), and a control group (Group 4) with 15 dogs per group. Each animal had the following determined: serum urea and creatinine, urea: creatinine ratio, cystatin-C, cTnI, blood lactate, plasma NT-proBNP, fractional shortening (FS), and blood pressure. The median NT-proBNP value in Groups 1–4 was 246, 650, 638, and 106 pmol/l. All 3 babesiosis groups had a statistically elevated NT-proBNP level compared to the control group and Groups 2 and 3 showed significantly higher values compared to Group 1. Median cTnI in Group 1–3 was 0.39, 0.4, and 1.45 ng/ml, respectively with the control group having concentrations below the detection limit (0.2 ng/ml). There was a significant difference in cTnI concentration between the control group and group 3 but no statistical difference between the other babesiosis groups. The study concluded that dogs with babesiosis showed elevated levels NT-proBNP and the more severe the disease process the greater the elevation. This elevation is earlier or independent of the increased cTnI.en_US
dc.description.urihttp://www.elsevier.com/locate/vetparen_US
dc.identifier.citationRemo Lobetti, Robert Kirberger, Ninette Keller, Frank Kettner & Eran Dvir, NT-ProBNP and cardiac troponin I in virulent canine babesiosis, Veterinary Parasitology, vol. 190, no. 3-4, pp. 333-339, (2012) doi: 10.1016/j.vetpar.2012.07.021en_US
dc.identifier.issn0304-4017 (print)
dc.identifier.issn1873-2550 (online)
dc.identifier.other10.1016/j.vetpar.2012.07.021
dc.identifier.other7004586182
dc.identifier.other7004445917
dc.identifier.otherN-8699-2014
dc.identifier.urihttp://hdl.handle.net/2263/20697
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2012 Elsevier. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Veterinary Parasitology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Veterinary Parasitology, vol 190, issue 3-4, 21 December 2012, doi: 10.1016/j.vetpar.2012.07.021.en_US
dc.subjectCardiac biomarkersen_US
dc.subjectBNPen_US
dc.subjectTroponinen_US
dc.subjectDogsen_US
dc.titleNT-ProBNP and cardiac troponin I in virulent canine babesiosisen_US
dc.typePostprint Articleen_US

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