Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine

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Authors

Camara, Djeneb
Bisanz, Cordelia
Barette, Caroline
Van Daele, Jeroen
Human, Esmare
Barnard, Bernice
Van der Straeten, Dominique
Stove, Christophe P.
Lambert, Willy E.
Douce, Roland

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American Society for Biochemistry and Molecular Biology

Abstract

BACKGROUND: pABA biosynthesis is a potential target for antifolate drugs. RESULTS: Rubreserine inhibits GAT-ADCS, an enzyme involved in pABA biosynthesis, and decreased the folate content in Arabidopsis and Toxoplasma. CONCLUSION: Specific inhibition of pABA synthesis induces growth limitation of plants and apicomplexan parasites. SIGNIFICANCE: GAT-ADCS is a valuable target in eukaryotes, and rubreserine is a novel scaffold for anti-parasitic drugs.

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Keywords

pABA biosynthesis, GAT-ADCS, Folate, Arabidopsis, Apicomplexa

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Citation

Camara, D, Bisanz, C, Barette, C, Van Daele, J, Human, E, Barnard, B, Van der Straeten, D, Stove, CP, Lambert, WE, Douce, R, Marechal, E, Brikholtz, LM, Cesbron-Delauw, MF, Dumas, R & Rebeille, F 2012, 'Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine', Journal of Biological Chemistry, vol. 287, no. 26, pp. 22367-22376.