Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine
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Date
Authors
Camara, Djeneb
Bisanz, Cordelia
Barette, Caroline
Van Daele, Jeroen
Human, Esmare
Barnard, Bernice
Van der Straeten, Dominique
Stove, Christophe P.
Lambert, Willy E.
Douce, Roland
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Biochemistry and Molecular Biology
Abstract
BACKGROUND: pABA biosynthesis is a potential target for antifolate drugs. RESULTS: Rubreserine inhibits GAT-ADCS, an enzyme involved in pABA biosynthesis, and decreased the folate content in Arabidopsis and Toxoplasma. CONCLUSION: Specific inhibition of pABA synthesis induces growth limitation of plants and apicomplexan parasites. SIGNIFICANCE: GAT-ADCS is a valuable target in eukaryotes, and rubreserine is a novel scaffold for anti-parasitic drugs.
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Keywords
pABA biosynthesis, GAT-ADCS, Folate, Arabidopsis, Apicomplexa
Sustainable Development Goals
Citation
Camara, D, Bisanz, C, Barette, C, Van Daele, J, Human, E, Barnard, B, Van der Straeten, D, Stove, CP, Lambert, WE, Douce, R, Marechal, E, Brikholtz, LM, Cesbron-Delauw, MF, Dumas, R & Rebeille, F 2012, 'Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine', Journal of Biological Chemistry, vol. 287, no. 26, pp. 22367-22376.