Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine

Camara, Djeneb; Bisanz, Cordelia; Barette, Caroline; Van Daele, Jeroen; Human, Esmare; Barnard, Bernice; Van der Straeten, Dominique; Stove, Christophe P.; Lambert, Willy E.; Douce, Roland; Marechal, Eric; Birkholtz, Lyn-Marie; Cesbron-Delauw, Marie-France; Dumas, Renaud; Rebeille, Fabrice

dc.contributor.author	Camara, Djeneb
dc.contributor.author	Bisanz, Cordelia
dc.contributor.author	Barette, Caroline
dc.contributor.author	Van Daele, Jeroen
dc.contributor.author	Human, Esmare
dc.contributor.author	Barnard, Bernice
dc.contributor.author	Van der Straeten, Dominique
dc.contributor.author	Stove, Christophe P.
dc.contributor.author	Lambert, Willy E.
dc.contributor.author	Douce, Roland
dc.contributor.author	Marechal, Eric
dc.contributor.author	Birkholtz, Lyn-Marie
dc.contributor.author	Cesbron-Delauw, Marie-France
dc.contributor.author	Dumas, Renaud
dc.contributor.author	Rebeille, Fabrice
dc.date.accessioned	2012-10-02T06:31:20Z
dc.date.available	2012-10-02T06:31:20Z
dc.date.issued	2012-05
dc.description.abstract	BACKGROUND: pABA biosynthesis is a potential target for antifolate drugs. RESULTS: Rubreserine inhibits GAT-ADCS, an enzyme involved in pABA biosynthesis, and decreased the folate content in Arabidopsis and Toxoplasma. CONCLUSION: Specific inhibition of pABA synthesis induces growth limitation of plants and apicomplexan parasites. SIGNIFICANCE: GAT-ADCS is a valuable target in eukaryotes, and rubreserine is a novel scaffold for anti-parasitic drugs.	en_US
dc.description.sponsorship	Ghent University Grant BOF09-GOA-004 and an Agence Nationale de la Recherche PlasmoExpress grant.	en_US
dc.description.uri	http://www.jbc.org/cgi/doi/10.1074/jbc.M112.365833	en_US
dc.identifier.citation	Camara, D, Bisanz, C, Barette, C, Van Daele, J, Human, E, Barnard, B, Van der Straeten, D, Stove, CP, Lambert, WE, Douce, R, Marechal, E, Brikholtz, LM, Cesbron-Delauw, MF, Dumas, R & Rebeille, F 2012, 'Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine', Journal of Biological Chemistry, vol. 287, no. 26, pp. 22367-22376.	en_US
dc.identifier.issn	0021-9258 (print)
dc.identifier.issn	1083-351X (online)
dc.identifier.other	10.1074/jbc.M112.365833
dc.identifier.uri	http://hdl.handle.net/2263/19945
dc.language.iso	en	en_US
dc.publisher	American Society for Biochemistry and Molecular Biology	en_US
dc.rights	© 2012 by The American Society for Biochemistry and Molecular Biology, Inc. This research was originally published: Camara, D; Bisanz, C; Barette, C; Van Daele, J; Human, E; Barnard, B; Van Der Straeten, D; Stove, CP; Lambert, WE; Douce, R; Marechal, E; Birkholtz, LM; Cesbron-Delauw, MF; Dumas, R; Rebeille, F, Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine, Journal of Biological Chemistry, 2012, vol. 287, pp 22367-22376.	en_US
dc.subject	pABA biosynthesis	en_US
dc.subject	GAT-ADCS	en_US
dc.subject	Folate	en_US
dc.subject	Arabidopsis	en_US
dc.subject	Apicomplexa	en_US
dc.title	Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine	en_US
dc.type	Postprint Article	en_US