Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine
| dc.contributor.author | Camara, Djeneb | |
| dc.contributor.author | Bisanz, Cordelia | |
| dc.contributor.author | Barette, Caroline | |
| dc.contributor.author | Van Daele, Jeroen | |
| dc.contributor.author | Human, Esmare | |
| dc.contributor.author | Barnard, Bernice | |
| dc.contributor.author | Van der Straeten, Dominique | |
| dc.contributor.author | Stove, Christophe P. | |
| dc.contributor.author | Lambert, Willy E. | |
| dc.contributor.author | Douce, Roland | |
| dc.contributor.author | Marechal, Eric | |
| dc.contributor.author | Birkholtz, Lyn-Marie | |
| dc.contributor.author | Cesbron-Delauw, Marie-France | |
| dc.contributor.author | Dumas, Renaud | |
| dc.contributor.author | Rebeille, Fabrice | |
| dc.date.accessioned | 2012-10-02T06:31:20Z | |
| dc.date.available | 2012-10-02T06:31:20Z | |
| dc.date.issued | 2012-05 | |
| dc.description.abstract | BACKGROUND: pABA biosynthesis is a potential target for antifolate drugs. RESULTS: Rubreserine inhibits GAT-ADCS, an enzyme involved in pABA biosynthesis, and decreased the folate content in Arabidopsis and Toxoplasma. CONCLUSION: Specific inhibition of pABA synthesis induces growth limitation of plants and apicomplexan parasites. SIGNIFICANCE: GAT-ADCS is a valuable target in eukaryotes, and rubreserine is a novel scaffold for anti-parasitic drugs. | en_US |
| dc.description.sponsorship | Ghent University Grant BOF09-GOA-004 and an Agence Nationale de la Recherche PlasmoExpress grant. | en_US |
| dc.description.uri | http://www.jbc.org/cgi/doi/10.1074/jbc.M112.365833 | en_US |
| dc.identifier.citation | Camara, D, Bisanz, C, Barette, C, Van Daele, J, Human, E, Barnard, B, Van der Straeten, D, Stove, CP, Lambert, WE, Douce, R, Marechal, E, Brikholtz, LM, Cesbron-Delauw, MF, Dumas, R & Rebeille, F 2012, 'Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine', Journal of Biological Chemistry, vol. 287, no. 26, pp. 22367-22376. | en_US |
| dc.identifier.issn | 0021-9258 (print) | |
| dc.identifier.issn | 1083-351X (online) | |
| dc.identifier.other | 10.1074/jbc.M112.365833 | |
| dc.identifier.uri | http://hdl.handle.net/2263/19945 | |
| dc.language.iso | en | en_US |
| dc.publisher | American Society for Biochemistry and Molecular Biology | en_US |
| dc.rights | © 2012 by The American Society for Biochemistry and Molecular Biology, Inc. This research was originally published: Camara, D; Bisanz, C; Barette, C; Van Daele, J; Human, E; Barnard, B; Van Der Straeten, D; Stove, CP; Lambert, WE; Douce, R; Marechal, E; Birkholtz, LM; Cesbron-Delauw, MF; Dumas, R; Rebeille, F, Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine, Journal of Biological Chemistry, 2012, vol. 287, pp 22367-22376. | en_US |
| dc.subject | pABA biosynthesis | en_US |
| dc.subject | GAT-ADCS | en_US |
| dc.subject | Folate | en_US |
| dc.subject | Arabidopsis | en_US |
| dc.subject | Apicomplexa | en_US |
| dc.title | Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine | en_US |
| dc.type | Postprint Article | en_US |