dc.contributor.author |
Venter, Marietjie
|
|
dc.contributor.author |
Van Niekerk, Stephanie
|
|
dc.contributor.author |
Rakgantso, Andronica
|
|
dc.contributor.author |
Bent, Nicola
|
|
dc.date.accessioned |
2012-07-20T13:24:50Z |
|
dc.date.available |
2012-07-20T13:24:50Z |
|
dc.date.issued |
2011-08 |
|
dc.description.abstract |
Respiratory syncytial virus (RSV) G protein deletion mutants replicate effectively in vitro but have not been detected in nature. Subtyping of RSV strains in hospitalized children in South Africa identified G protein PCR amplicons significantly reduced in size in 2 out of 209 clinical specimens screened over 4 years. Sequence analysis revealed subtype B strains lacking nearly the entire G protein ectodomain in one HIV-positive and one HIV-exposed child hospitalized with pneumonia. The association of clinical strains lacking most of the G protein with lower respiratory tract infection in immunocompromised children may have implications for RSV vaccine development. |
en_US |
dc.description.sponsorship |
Poliomyelitis Research Foundation |
en_US |
dc.description.uri |
http://jvi.asm.org/ |
en_US |
dc.identifier.citation |
Venter, M, Van Niekerk, S, Rakgantso, A & Bent, N 2011, 'Identification of deletion mutant respiratory syncytial virus strains lacking most of the G protein in immunocompromised children with pneumonia in South Africa', Journal of Virology, vol. 85, no. 16, pp. 8453-8457. |
en_US |
dc.identifier.issn |
0022-538x (print) |
|
dc.identifier.issn |
1098-5514 (online) |
|
dc.identifier.other |
10.1128/JVI.00674-11 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/19469 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
American Society for Microbiology |
en_US |
dc.rights |
© 2011 American Society for Microbiology |
en_US |
dc.subject |
Respiratory syncytial virus (RSV) |
en_US |
dc.subject |
Identification |
en_US |
dc.subject |
Pneumonia |
en_US |
dc.subject |
South Africa ( SA ) |
en_US |
dc.subject.lcsh |
Immunodeficiency -- Research |
en |
dc.subject.lcsh |
Poliomyelitis vaccine -- Research |
en |
dc.title |
Identification of deletion mutant respiratory syncytial virus strains lacking most of the G protein in immunocompromised children with pneumonia in South Africa |
en_US |
dc.type |
Postprint Article |
en_US |