Identification of deletion mutant respiratory syncytial virus strains lacking most of the G protein in immunocompromised children with pneumonia in South Africa

dc.contributor.authorVenter, Marietjie
dc.contributor.authorVan Niekerk, Stephanie
dc.contributor.authorRakgantso, Andronica
dc.contributor.authorBent, Nicola
dc.date.accessioned2012-07-20T13:24:50Z
dc.date.available2012-07-20T13:24:50Z
dc.date.issued2011-08
dc.description.abstractRespiratory syncytial virus (RSV) G protein deletion mutants replicate effectively in vitro but have not been detected in nature. Subtyping of RSV strains in hospitalized children in South Africa identified G protein PCR amplicons significantly reduced in size in 2 out of 209 clinical specimens screened over 4 years. Sequence analysis revealed subtype B strains lacking nearly the entire G protein ectodomain in one HIV-positive and one HIV-exposed child hospitalized with pneumonia. The association of clinical strains lacking most of the G protein with lower respiratory tract infection in immunocompromised children may have implications for RSV vaccine development.en_US
dc.description.sponsorshipPoliomyelitis Research Foundationen_US
dc.description.urihttp://jvi.asm.org/en_US
dc.identifier.citationVenter, M, Van Niekerk, S, Rakgantso, A & Bent, N 2011, 'Identification of deletion mutant respiratory syncytial virus strains lacking most of the G protein in immunocompromised children with pneumonia in South Africa', Journal of Virology, vol. 85, no. 16, pp. 8453-8457.en_US
dc.identifier.issn0022-538x (print)
dc.identifier.issn1098-5514 (online)
dc.identifier.other10.1128/​JVI.00674-11
dc.identifier.urihttp://hdl.handle.net/2263/19469
dc.language.isoenen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.rights© 2011 American Society for Microbiologyen_US
dc.subjectRespiratory syncytial virus (RSV)en_US
dc.subjectIdentificationen_US
dc.subjectPneumoniaen_US
dc.subjectSouth Africa ( SA )en_US
dc.subject.lcshImmunodeficiency -- Researchen
dc.subject.lcshPoliomyelitis vaccine -- Researchen
dc.titleIdentification of deletion mutant respiratory syncytial virus strains lacking most of the G protein in immunocompromised children with pneumonia in South Africaen_US
dc.typePostprint Articleen_US

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