Identification of deletion mutant respiratory syncytial virus strains lacking most of the G protein in immunocompromised children with pneumonia in South Africa
dc.contributor.author | Venter, Marietjie | |
dc.contributor.author | Van Niekerk, Stephanie | |
dc.contributor.author | Rakgantso, Andronica | |
dc.contributor.author | Bent, Nicola | |
dc.date.accessioned | 2012-07-20T13:24:50Z | |
dc.date.available | 2012-07-20T13:24:50Z | |
dc.date.issued | 2011-08 | |
dc.description.abstract | Respiratory syncytial virus (RSV) G protein deletion mutants replicate effectively in vitro but have not been detected in nature. Subtyping of RSV strains in hospitalized children in South Africa identified G protein PCR amplicons significantly reduced in size in 2 out of 209 clinical specimens screened over 4 years. Sequence analysis revealed subtype B strains lacking nearly the entire G protein ectodomain in one HIV-positive and one HIV-exposed child hospitalized with pneumonia. The association of clinical strains lacking most of the G protein with lower respiratory tract infection in immunocompromised children may have implications for RSV vaccine development. | en_US |
dc.description.sponsorship | Poliomyelitis Research Foundation | en_US |
dc.description.uri | http://jvi.asm.org/ | en_US |
dc.identifier.citation | Venter, M, Van Niekerk, S, Rakgantso, A & Bent, N 2011, 'Identification of deletion mutant respiratory syncytial virus strains lacking most of the G protein in immunocompromised children with pneumonia in South Africa', Journal of Virology, vol. 85, no. 16, pp. 8453-8457. | en_US |
dc.identifier.issn | 0022-538x (print) | |
dc.identifier.issn | 1098-5514 (online) | |
dc.identifier.other | 10.1128/JVI.00674-11 | |
dc.identifier.uri | http://hdl.handle.net/2263/19469 | |
dc.language.iso | en | en_US |
dc.publisher | American Society for Microbiology | en_US |
dc.rights | © 2011 American Society for Microbiology | en_US |
dc.subject | Respiratory syncytial virus (RSV) | en_US |
dc.subject | Identification | en_US |
dc.subject | Pneumonia | en_US |
dc.subject | South Africa ( SA ) | en_US |
dc.subject.lcsh | Immunodeficiency -- Research | en |
dc.subject.lcsh | Poliomyelitis vaccine -- Research | en |
dc.title | Identification of deletion mutant respiratory syncytial virus strains lacking most of the G protein in immunocompromised children with pneumonia in South Africa | en_US |
dc.type | Postprint Article | en_US |