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Browsing Research Articles (Surgery) by Subject "Therapeutic targets"

Now showing items 1-3 of 3

Many voices in a choir: tumor-induced neurogenesis and neuronal driven alternative splicing sound like suspects in tumor growth and dissemination

Dlamini, Zodwa; Mathabe, Kgomotso; Padayachy, Llewellyn; Marima, Rahaba; Evangelou, George; Syrigos, Konstantinos N.; Bianchi, Arianna; Lolas, Georgios; Hull, Rodney (MDPI, 2021-05)

During development, as tissues expand and grow, they require circulatory, lymphatic, and nervous system expansion for proper function and support. Similarly, as tumors arise and develop, they also require the expansion ...
Microbiomes, epigenomics, immune response, and splicing signatures interplay : potential use of combination of regulatory pathways as targets for malignant mesothelioma

Setlai, Botle Precious; Mkhize-Kwitshana, Zilungile Lynette; Mehrotra, Ravi; Mulaudzi, Thanyani Victor; Dlamini, Zodwa (MDPI, 2022-08-12)

Malignant mesotheliomas (MM) are hard to treat malignancies with poor prognosis and high mortality rates. This cancer is highly misdiagnosed in Sub-Saharan African countries. According to literature, the incidence of MM ...
Prognostic alternative splicing signatures in esophageal carcinoma

Dlamini, Zodwa; Hull, Rodney; Mbatha, Sikhumbuzo Z.; Alaouna, Mohammed; Qiao, You-Lin; Yu, Herbert; Chatziioannou, Aristotelis (Dove Medical Press, 2021)

Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of ...

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Browsing Research Articles (Surgery) by Subject "Therapeutic targets"

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