Browsing Surgery by Subject "Gene expression"

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Increased expression of plakoglobin is associated with upregulated MAPK and PI3K/AKT signalling pathways in early resectable pancreatic ductal adenocarcinoma

Nweke, Ekene Emmanuel; Ntwasa, Monde; Brand, Martin; Devar, John; Smith, Martin; Candy, Geoffrey (Spandidos, 2020-06)

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types, and it is associated with a 5‑year survival rate of <10% due to limited early detection methods and ineffective therapeutic options. Thus, an ...
Synergistic in-vitro effects of combining an antiglycolytic, 3-bromopyruvate, and a bromodomain-4 inhibitor on U937 myeloid leukemia cells

Kapp, Nicolette; Stander, Xiao Xing; Stander, Barend Andre (Lippincott, Williams & Wilkins, 2018-06)

This project investigated the in-vitro effects of a glycolytic inhibitor, 3-bromopyruvate (3-BrP), in combination with and a new in silico-designed inhibitor of the bromodomain-4 (BRD-4) protein, ITH-47, on the U937 acute ...

Now showing items 1-2 of 2

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