Browsing Surgery by Subject "Drug resistance"

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MicroRNA and alternative mRNA splicing events in cancer drug response/resistance : potent therapeutic targets

Marima, Rahaba; Francies, Flavia Zita; Hull, Rodney; Molefi, Thulo; Oyomno, Meryl; Khanyile, Richard; Mbatha, Sikhumbuzo Z.; Bates, David Owen; Dlamini, Zodwa (MDPI, 2021-12-02)

Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer that lead to changes in gene expression include altered microRNA ...
Targeting stem cells in the colorectal cancer microenvironment to avert drug resistance in pursuit of novel oncotherapies

Damane, Botle Precious; Marima, Rahaba; Mulaudzi, Thanyani; Dlamini, Zodwa (Biolife Sas, 2023-09)

Several studies have demonstrated the heightened prevalence of colorectal cancer (CRC) among young black men. Most of these men present with already metastasized CRC. Cancer stem cells (CSCs) play a pivotal role in CRC ...

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