Browsing Research Articles (Genetics) by Title

Browsing Research Articles (Genetics) by Title

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  • Machine learning uses chemo-transcriptomic profiles to stratify antimalarial compounds with similar mode of action 
    Van Heerden, Ashleigh; Van Wyk, Roelof Daniel Jacobus; Birkholtz, Lyn-Marie (Frontiers Media, 2021-06)
    The rapid development of antimalarial resistance motivates the continued search for novel compounds with a mode of action (MoA) different to current antimalarials. Phenotypic screening has delivered thousands of promising ...
  • Malaria vectors in the Democratic Republic of the Congo : the mechanisms that confer insecticide resistance in Anopheles gambiae and Anopheles funestus 
    Nardini, Luisa; Hunt, Richard H.; Dahan‑Moss, Yael L.; Christie, Nanette; Christian, Riann N.; Coetzee, Maureen; Koekemoer, Lizette L. (BioMed Central, 2017-11-07)
    BACKGROUND : The Democratic Republic of the Congo (DRC) is characterized as a holoendemic malaria area with the main vectors being Anopheles funestus and members of the Anopheles gambiae complex. Due to political ...
  • Management of hybridization in an endemic species : decision making in the face of imperfect information in the case of the black wildebeest-Connochaetes gnou 
    Grobler, J. Paul; Rushworth, Ian; Brink, James Simpson; Kotze, Antoinette; Bloomer, Paulette; Reilly, Brian Kevin; Vrahimis, Savvas (Springer, 2011-10)
    Hybridization between introduced and endemic ungulates, resulting from Anthropogenic actions, have been reported for several species. Several studies of such events contain the common themes of extralimital movements, ...
  • MAT gene idiomorphs suggest a heterothallic sexual cycle in a predominantly asexual and important pine pathogen 
    Bihon, Wubetu; Wingfield, Michael J.; Slippers, Bernard; Duong, Tuan A.; Wingfield, Brenda D. (Elsevier, 2014-01)
    Diplodia pinea (=Sphaeropsis sapinea) is a well-known and economically important latent pathogen of Pinus spp. in many parts of the world. Despite intensive scrutiny, its sexual state has never been observed and the ...
  • Maternal effects on tree phenotypes : considering the microbiome 
    Vivas, Maria; Kemler, Martin; Slippers, Bernard (Elsevier, 2015-09)
    The biotic and abiotic environmental experience of plants can influence the offspring without any changes in DNA sequence. These effects can modulate the development of the progeny and its interaction with micro-organisms. ...
  • Maternal effects should be considered in the establishment of forestry plantations 
    Vivas, Maria; Wingfield, Michael J.; Slippers, Bernard (Elsevier, 2020-03)
    Breeding strategies for plants focus on the genetic influence on their phenotypes. However, the phenotype is not only the outcome of the genotype or the environmental conditions under which plants grow. It is important to ...
  • Maternal environment regulates morphological and physiological traits in Eucalyptus grandis 
    Vivas, Maria; Rolo, Victor; Wingfield, Michael J.; Slippers, Bernard (Elsevier, 2019-01)
    The phenotype of a plant can be shaped by the biotic and abiotic conditions to which their parents are subjected. This phenotypic plasticity known as maternal environmental effect occurs regardless of the changes in the ...
  • Mating genes in Calonectria and evidence for a heterothallic ancestral state 
    Li, JieQiong; Wingfield, Brenda D.; Wingfield, Michael J.; Barnes, Irene; Fourie, Arista; Crous, Pedro W.; Chen, S.F. (Naturalis Biodiversity Center and Centraalbureau voor Schimmelcultures, 2020-03-17)
    The genus Calonectria includes many important plant pathogens with a wide global distribution. In order to better understand the reproductive biology of these fungi, we characterised the structure of the mating type ...
  • Mating strategy and mating type distribution in six global populations of the Eucalyptus foliar pathogen Teratosphaeria destructans 
    Havenga, Minette; Wingfield, Brenda D.; Wingfield, Michael J.; Roets, Francois; Dreyer, Leanne Laurette; Tatham, Catherine; Duong, Tuan A.; Wilken, Pieter Markus; Chen, ShuaiFei; Aylward, Janneke (Elsevier, 2020-04)
    Teratosphaeria destructans is an aggressive fungal pathogen causing leaf and shoot blight on young Eucalyptus trees in plantations. The disease occurs across tropical and subtropical regions of South East Asia and has ...
  • The mating system of the Eucalyptus canker pathogen Chrysoporthe austroafricana and closely related species 
    Kanzi, Aquillah M.; Steenkamp, Emma Theodora; Van der Merwe, Nicolaas Albertus (Albie); Wingfield, Brenda D. (Elsevier, 2019-02)
    Fungi in the genus Chrysoporthe are economically important canker pathogens of commercially grown Eucalyptus species and native Myrtales. Before the current study, homothallism was widely accepted as the mating system of ...
  • The mechanism of the amidases : mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning 
    Weber, Brandon W.; Kimani, Serah W.; Varsani, Arvind; Cowan, Don A.; Hunter, Roger; Venter, Gerhard A.; Gumbart, James C.; Sewell, B. Trevor (American Society for Biochemistry and Molecular Biology, 2013)
    All known nitrilase superfamily amidase and carbamoylase structures have an additional glutamate that is hydrogen bonded to the catalytic lysine in addition to the Glu, Lys, Cys “catalytic triad.” In the amidase from ...
  • Mechanisms that influence sex ratio variation in the invasive hymenopteran Sirex noctilio in South Africa 
    Queffelec, Josephine; Wooding, Amy L.; Greeff, Jaco M. (Jacobus Maree); Garnas, Jeffrey R.; Hurley, Brett Phillip; Wingfield, Brenda D.; Slippers, Bernard (Wiley Open Access, 2019-07)
    Sirex noctilio is an economically important invasive pest of commercial pine forestry in the Southern Hemisphere. Newly established invasive populations of this woodwasp are characterized by highly male‐biased sex ratios ...
  • Meeting report : 1st International Functional Metagenomics Workshop May 7–8, 2012, St. Jacobs, Ontario, Canada 
    Engel, Katja; Ashby, Deborah; Brady, Sean F.; Cowan, Don A.; Doemer, John; Edwards, Elizabeth A.; Fiebig, Klaus; Martens, Eric C.; McCormac, Dennis; Mead, David A.; Miyazaki, Kentaro; Moreno-Hagelsieb, Gabriel; O'gara, Fergal; Reid, Alexandra; Rose, David R.; Simonet, Pascal; Sjoling, Sara; Smalla, Kornelia; Streit, Wolfgang R.; Tedman-Jones, Jennifer; Valla, Svein; Wellington, Elizabeth; Wu, Cheng-Cang; Liles, Mark R.; Neufeld, Josh D.; Sessitsch, Angela; Charles, Trevor C. (2013)
    This report summarizes the events of the 1st International Functional Metagenomics Work-shop. The workshop was held on May 7 and 8, 2012, in St. Jacobs, Ontario, Canada and was focused on building an international functional ...
  • The Meloidogyne graminicola effector Mg16820 is secreted in the apoplast and cytoplasm to suppress plant host defense responses 
    Naalden, Diana; Haegeman, Annelies; De Almeida-Engler, Janice; Birhane Eshetu, Firehiwot; Bauters, Lander; Gheysen Godelieve (Wiley, 2018-11)
    On invasion of roots, plant‐parasitic nematodes secrete effectors to manipulate the cellular regulation of the host to promote parasitism. The root‐knot nematode Meloidogyne graminicola is one of the most damaging nematodes ...
  • Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers 
    Qian, Frank; Rookus, Matti A.; Leslie, Goska; Risch, Harvey A.; Greene, Mark H.; Aalfs, Cora M.; Adank, Muriel A.; Adlard, Julian; Agnarsson, Bjarni A.; Ahmed, Munaza; Aittomäki, Kristiina; Andrulis, Irene L.; Arnold, Norbert; Arun, Banu K.; Ausems, Margreet G.E.M.; Azzollini, Jacopo; Barrowdale, Daniel; Barwell, Julian; Benitez, Javier; Białkowska, Katarzyna; Bonadona, Valérie; Borde, Julika; Borg, Ake; Bradbury, Angela R.; Brunet, Joan; Buys, Saundra S.; Caldes, Trinidad; Caligo, Maria A.; Campbell, Ian; Carter, Jonathan; Chiquette, Jocelyne; Chung, Wendy K.; Claes, Kathleen B.M.; Collee, J. Margriet; Collonge-Rame, Marie-Agnes; Couch, Fergus J.; Daly, Mary B.; Delnatte, Capucine; Diez, Orland; Domchek, Susan M.; Dorfling, Cecilia Maria; Eason, Jacqueline; Easton, Douglas F.; Eeles, Ros; Engel, Christoph; Evans, D. Gareth; Faivre, Laurence; Feliubadalo, Lidia; Foretova, Lenka; Friedman, Eitan; Frost, Debra; Ganz, Patricia A.; Garber, Judy; Garcia-Barberan, Vanesa; Gehrig, Andrea; Glendon, Gord; Godwin, Andrew K.; Gomez Garcia, Encarna B.; Hamann, Ute; Hauke, Jan; Hopper, John L.; Hulick, Peter J.; Imyanitov, Evgeny N.; Isaacs, Claudine; Izatt, Louise; Jakubowska, Anna; Janavicius, Ramunas; John, Esther M.; Karlan, Beth Y.; Kets, Carolien M.; Laitman, Yael; Lazaro, Conxi; Leroux, Dominique; Lester, Jenny; Lesueur, Fabienne; Loud, Jennifer T.; Lubinski, Jan; Lukomska, Alicja; McGuffog, Lesley; Mebirouk, Noura; Meijers-Heijboer, Hanne E.J.; Meindl, Alfons; Miller, Austin; Montagna, Marco; Mooij, Thea M.; Mouret-Fourme, Emmanuelle; Nathanson, Katherine L.; Nehoray, Bita; Neuhausen, Susan L.; Nevanlinna, Heli; Nielsen, Finn C.; Offit, Kenneth; Olah, Edith; Ong, Kai-ren; Oosterwijk, Jan C.; Ottini, Laura; Parsons, Michael T.; Peterlongo, Paolo; Pfeiler, Georg; Pradhan, Nisha; Radice, Paolo; Ramus, Susan J.; Rantala, Johanna; Rennert, Gad; Robson, Mark; Rodriguez, Gustavo C.; Salani, Ritu; Scheuner, Maren T.; Schmutzler, Rita K.; Shah, Payal D.; Side, Lucy E.; Simard, Jacques; Singer, Christian F.; Steinemann, Doris; Stoppa-Lyonnet, Dominique; Tan, Yen Yen; Teixeira, Manuel R.; Terry, Mary Beth; Thomassen, Mads; Tischkowitz, Marc; Tognazzo, Silvia; Toland, Amanda Ewart; Tung, Nadine; Van Asperen, Christi J.; Van Engelen, Klaartje; Jansen van Rensburg, Elizabeth; Venat-Bouvet, Laurence; Vierstraete, Jeroen; Wagner, Gabriel; Walker, Lisa; Weitzel, Jeffrey N.; Yannoukakos, Drakoulis; KConFab Investigators; HEBON Investigators; GEMO Study Collaborators; EMBRACE Collaborators; Antoniou, Antonis C.; Goldgar, David E.; Olopade, Olufunmilayo I.; Chenevix-Trench, Georgia; Rebbeck, Timothy R.; Huo, Dezheng (Springer Nature, 2019-07)
    BACKGROUND : Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. METHODS : We applied ...
  • Metabolomic and molecular signatures of Mascarene Aloes using a multidisciplinary approach 
    Govinden-Soulange, J.; Lobine, D.; Frederich, M.; Kodja, H.; Coetzee, Martin Petrus Albertus; Ranghoo-Sanmukhiya, V.M. (Elsevier, 2017-01)
    In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect to Aloe vera. ...
  • Metabolomic fingerprinting of potato cultivars differing in susceptibility to Spongospora subterranea f. sp. subterranea root infection 
    Lekota, Moleboheng; Modisane, Kehumile J.; Apostolides, Zeno; Van der Waals, Jacqueline Elise (MDPI Publishing, 2020-05-27)
    Plants defend themselves from pathogens by producing bioactive defense chemicals. The biochemical mechanisms relating to quantitative resistance of potato to root infection by Spongospora subterranea f. sp. subterranea ...
  • Metabolomics for a millenniums-old crop : tea plant (Camellia sinensis) 
    Jiang, Chen-Kai; Ma, Jian-Qiang; Apostolides, Zeno; Chen, Liang (American Chemical Society, 2019-05)
    Tea cultivation and utilization dates back to antiquity. Today it is the most widely consumed beverage on earth due to its pleasant taste and several beneficial health properties attributed to specific metabolites. ...
  • Metagenomic analysis of the viral community in Namib desert hypoliths 
    Adriaenssens, Evelien M.; Van Zyl, Leonardo J.; De Maayer, Pieter; Rubagotti, Enrico; Rybicki, Edward P.; Tuffin, Marla I.; Cowan, Don A. (Wiley-Blackwell, 2015-02)
    Hypolithic microbial communities are specialized desert communities inhabiting the underside of translucent rocks where they are sheltered from harsh environmental conditions. Here, we present the first study of the viral ...
  • Metagenomic analysis provides insights into functional capacity in a hyperarid desert soil niche community 
    Vikram, Surendra; Guerrero, Leandro D.; Makhalanyane, Thulani P.; Le, Phuong T.; Seely, Mary; Cowan, Don A. (Wiley, 2016-06)
    Environmental stressors such as low water activity and temperature extremes impose severe limitations on the productivity of soils in hyperarid deserts. In such ecosystems, macroscopic communities are often restricted ...