Browsing Research Articles (Genetics) by Title

Browsing Research Articles (Genetics) by Title

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  • Namib Desert dune/interdune transects exhibit habitat-specific edaphic bacterial communities 
    Ronca, Sandra; Ramond, Jean-Baptiste; Jones, Brian E.; Seely, Mary; Cowan, Don A. (Frontiers Research Foundation, 2015-09-04)
    The sand dunes and inter-dune zones of the hyper-arid central Namib Desert represent heterogeneous soil habitats. As little is known about their indigenous edaphic bacterial communities, we aimed to evaluate their diversity ...
  • Namib Desert edaphic bacterial, fungal and archaeal communities assemble through deterministic processes but are influenced by different abiotic parameters 
    Johnson, Riegardt M.; Ramond, Jean-Baptiste; Gunnigle, Eoin; Seely, Mary; Cowan, Don A. (Springer, 2017-01)
    The central Namib Desert is hyperarid, where limited plant growth ensures that biogeochemical processes are largely driven by microbial populations. Recent research has shown that niche partitioning is critically involved ...
  • Namib Desert primary productivity is driven by cryptic microbial community N-fixation 
    Ramond, Jean-Baptiste; Woodborne, Stephan M.; Hall, Grant; Seely, Mary; Cowan, Don A. (Nature Publishing Group, 2018-05-02)
    Carbon exchange in drylands is typically low, but during significant rainfall events (wet anomalies) drylands act as a C sink. During these anomalies the limitation on C uptake switches from water to nitrogen. In the ...
  • Nanoplankton : the dominant vector for carbon export across the Atlantic Southern Ocean in spring 
    Flynn, Raquel F.; Haraguchi, Lumi; Mcquaid, Jeff; Burger, Jessica M.; Lunga, Percy Mutseka; Stirnimann, Luca; Samanta, Saumik; Roychoudhury, Alakendra N.; Fawcett, Sarah E. (American Association for the Advancement of Science, 2023-12)
    Across the Southern Ocean, large (≥20 μm) diatoms are generally assumed to be the primary vector for carbon export, although this assumption derives mainly from summertime observations. Here, we investigated carbon production ...
  • Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products 
    Moyo, Phanankosi; Shamburger, William; Van der Watt, Mariette Elizabeth; Reader, Janette; De Sousa, Ana Carolina C.; Egan, Timothy J.; Maharaj, Vinesh J.; Bringmann, Gerhard; Birkholtz, Lyn-Marie (Elsevier, 2020-08)
    The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic asexual and sexual Plasmodium falciparum parasites is of utmost importance to achieve the ambitious goal of malaria elimination. Here, ...
  • Natural products : a potential source of malaria transmission blocking drugs? 
    Moyo, Phanankosi; Mugumbate, Grace; Eloff, Jacobus Nicolaas; Louw, Abraham Izak; Maharaj, Vinesh J.; Birkholtz, Lyn-Marie (MDPI Publishing, 2020-09-17)
    The ability to block human-to-mosquito and mosquito-to-human transmission of Plasmodium parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a ...
  • Natural products as lead compounds in drug discovery 
    Khazir, Jabeena; Cowan, Don A.; Mir, Bilal Ahmad (Taylor and Francis, 2013-05)
    This review surveys the diversity of natural products (NPs) derived from terrestrial plants, micro-organisms, marine organisms and fungi used in the treatment of various diseases. A wide spectrum of compounds derived ...
  • Navigating the transcriptional roadmap regulating plant secondary cell wall deposition 
    Hussey, Steven Grant; Mizrachi, Eshchar; Creux, Nicole Marie; Myburg, Alexander Andrew (2013-08-29)
    The current status of lignocellulosic biomass as an invaluable resource in industry, agriculture, and health has spurred increased interest in understanding the transcriptional regulation of secondary cell wall (SCW) ...
  • Nearby transposable elements impact plant stress gene regulatory networks : a meta-analysis in A. thaliana and S. lycopersicum 
    Deneweth, Jan; Van de Peer, Yves; Vermeirssen, Vanessa (BMC, 2022-01)
    BACKGROUND: Transposable elements (TE) make up a large portion of many plant genomes and are playing innovative roles in genome evolution. Several TEs can contribute to gene regulation by influencing expression of nearby ...
  • The neighborhood of the spike gene Is a hotspot for modular intertypic homologous and nonhomologous recombination in coronavirus genomes 
    Nikolaidis, Marios; Markoulatos, Panayotis; Van de Peer, Yves; Oliver, Stephen G.; Amoutzias, Grigorios D. (Oxford University Press, 2022-01)
    Coronaviruses (CoVs) have very large RNA viral genomes with a distinct genomic architecture of core and accessory open reading frames (ORFs). It is of utmost importance to understand their patterns and limits of homologous ...
  • Neotropical termite microbiomes as sources of novel plant cell wall degrading enzymes 
    Victorica, Matias Romero; Soria, Marcelo A.; Batista-Garcia, Ramon Alberto; Ceja-Navarro, Javier A.; Vikram, Surendra; Ortiz, Maximiliano; Ontanon, Ornella; Ghio, Silvina; Martínez-Avila, Liliana; Quintero García, Omar Jasiel; Etcheverry, Clara; Campos, Eleonora; Cowan, Don A.; Arneodo, Joel; Talia, Paola M. (Nature Publishing Group, 2020-03-02)
    In this study, we used shotgun metagenomic sequencing to characterise the microbial metabolic potential for lignocellulose transformation in the gut of two colonies of Argentine higher termite species with different ...
  • Network modelling unravels mechanisms of crosstalk between ethylene and salicylate signalling in potato 
    Ramsak, Živa; Coll, Anna; Stare, Tjaša; Tzfadia, Oren; Baebler, Špela; Van de Peer, Yves; Gruden, Kristina (American Society of Plant Biologists, 2018-09)
    To develop novel crop breeding strategies, it is crucial to understand the mechanisms underlying the interaction between plants and their pathogens. Network modeling represents a powerful tool that can unravel properties ...
  • Network-based identification of adaptive pathways in evolved ethanol-tolerant bacterial populations 
    Swings, Toon; Weytjens, Bram; Schalck, Thomas; Bonte, Camille; Verstraeten, Natalie; Michiels, Jan; Marchal, Kathleen (Oxford University Press, 2017-11)
    Efficient production of ethanol for use as a renewable fuel requires organisms with a high level of ethanol tolerance. However, this trait is complex and increased tolerance therefore requires mutations in multiple genes ...
  • New amidated 3,6-diphenylated imidazopyridazines with potent antiplasmodium activity are dual inhibitors of Plasmodium phosphatidylinositol-4-kinase and cGMP-dependent protein kinase 
    Cheuka, Peter Mubanga; Centani, Luyanda; Arendse, Lauren B.; Fienberg, Stephen; Wambua, Lynn; Renga, Shoneeze S.; Dziwornu, Godwin Akpeko; Kumar, Malkeet; Lawrence, Nina; Taylor, Dale; Wittlin, Sergio; Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Birkholtz, Lyn-Marie; Chibale, Kelly (American Chemical Society, 2021-01)
    Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation ...
  • New and interesting fungi. 4 
    Crous, Pedro W.; Hernandez-Restrepo, H.; Schumacher, R.K.; Cowan, Don A.; Maggs-Kolling, G.; Marais, E.; Wingfield, Michael J.; Yilmaz, Neriman; Adan, O.C.G.; Akulov, A.; Alvarez Duarte, E.; Berraf-Tebbal, A.; Bulgakov, T.S.; Carnegie, A.J.; De Beer, Z. Wilhelm; Decock, C.; Dijksterhuis, J.; Duong, Tuan A.; Eichmeier, A.; Hien, L.T.; Houbraken, J.A.M.P.; Khanh, T.N.; Liem, N.V.; Lombard, L.; Lutzoni, F.M.; Miadlikowska, J.M.; Nel, Wilma Janine; Pascoe, I.G.; Roets, F.; Roux, Jolanda; Samson, R.A.; Shen, M.; Spetik, M.; Thangavel, R.; Thanh, H.M.; Thao, L.D.; Van Nieuwenhuijzen, E.J.; Zhang, J.Q.; Zhang, Y.; Zhao, L.L.; Groenewald, Johannes Zacharias (Westerdijk Fungal Biodiversity Institute, 2021-04-28)
    An order, family and genus are validated, seven new genera, 35 new species, two new combinations, two epitypes, two lectotypes, and 17 interesting new host and / or geographical records are introduced in this study. Validated ...
  • New antidiabetic targets of α-glucosidase inhibitory peptides, SVPA, SEPA, STYV and STY: Inhibitory effects on dipeptidyl peptidase-IV and lipid accumulation in 3T3-L1 differentiated adipocytes with scavenging activities against methylglyoxal and reactive oxygen species 
    Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2020-12)
    Type 2 diabetes mellitus (T2DM) is a multifactorial disease that requires multiple therapeutic strategies for its management. Bioactive peptides with multiple anti-diabetic targets are attractive therapeutic molecules. The ...
  • New Botryosphaeriales on native red milkwood (Mimusops caffra) 
    Jami, Fahimeh; Marincowitz, Seonju; Slippers, Bernard; Wingfield, Michael J. (Springer, 2018-09)
    Fungi in the Botryosphaeriales (Ascomycetes) are common endophytes in woody plants with a wide global distribution and in some cases they are important tree pathogens. The aim of this study was to consider the possible ...
  • New Ceratocystis species associated with rapid death of Metrosideros polymorpha in Hawai'i 
    Barnes, Irene; Fourie, Arista; Wingfield, Michael J.; Harrington, T.C.; McNew, D.L.; Sugiyama, L.S.; Luiz, B.C.; Heller, W.P.; Keith, L.M. (Naturalis Biodiversity Center, 2018-03-27)
    The native ˋōhiˋa lehua (Metrosideros polymorpha) has cultural, biological and ecological significance to Hawai`i, but it is seriously threatened by a disease commonly referred to as rapid ˋōhiˋa death (ROD). Preliminary ...
  • New Ceratocystis species from Eucalyptus and Cunninghamia in South China 
    Liu, FeiFei; Mbenoun, Michael; Barnes, Irene; Roux, Jolanda; Wingfield, Michael J.; Li, GuoQing; Li, JieQiong; Chen, ShuaiFei (Springer, 2015-06)
    During routine surveys for possible fungal pathogens in the rapidly expanding plantations of Eucalyptus and Cunninghamia lanceolata in China, numerous isolates of unknown species in the genus Ceratocystis (Microascales) ...
  • New Ceratocystis species infecting coffee, cacao, citrus and native trees in Colombia 
    Van Wyk, Marelize; Wingfield, Brenda D.; Marin, M.; Wingfield, Michael J. (Springer, 2010-01)
    Ceratocystis fimbriata sensu lato includes a large number of plant and especially tree pathogens. In Colombia, isolates of this fungus cause a serious cankerstain disease on coffee as well as other fruit trees. Large ...